Ongoing, recruitingHuman Pharmacology (Phase I)- OtherInterventional

A study to learn about the taste of Vericiguat given in liquid form in healthy male participants aged 18 to 45 years

Researchers are conducting a study to understand the taste of a liquid version of a medicine called Vericiguat. This medicine is normally used to treat heart failure in adults, but this specific study is focused on how it tastes, particularly because it could be given to children in the future. They are enrolling healthy men between 18 and 45 years old to try the liquid medicine and describe its taste. This information is important for making sure that if this medicine is ever given to children, it's something they can take without too much difficulty, which is often a challenge with liquid medicines.

At a glance

Status

Ongoing, recruiting

Phase

Human Pharmacology (Phase I)- Other

Sponsor

Bayer AG

Enrolment target

Start

04 Jun 2024

Heart failure in children

What is this study about?

This study is all about taste! Researchers are trying to figure out what a liquid form of a medicine called Vericiguat tastes like. You might be wondering why taste is so important, especially for a medicine that treats heart failure in adults. Well, this particular study is looking ahead to a time when this medicine might be used for children who have heart failure.

Giving medicine to children can sometimes be tricky, especially if it has a strong or unpleasant taste. If a medicine tastes bad, children might refuse to take it, which means they won't get the treatment they need. By understanding how Vericiguat tastes in its liquid form, scientists can work on making it more palatable – that is, easier and more pleasant to take – for children in the future.

So, even though this study is for healthy adult men, the information they gather about the taste of the liquid medicine will be really helpful for developing a child-friendly version. It's an important step in making sure that effective medicines can be given easily to everyone who needs them, including our youngest patients.

Key takeaways

This study is about tasting a liquid medicine called Vericiguat.
It aims to help make future medicines easier for children to take.
Only healthy men aged 18-45 can take part.
Participation involves describing the taste of the liquid medicine.
Your feedback helps develop child-friendly treatments.

Who may be eligible?

This study is specifically looking for healthy adult men. To be considered for this study, you need to be aged between 18 and 45 years old.

As this is a study about the *taste* of a new liquid medicine, participants are expected to be generally healthy and not have any serious medical conditions that might affect how they taste things or how they react to the medicine. The researchers will check your health carefully to make sure you're a good fit for the study.

Since the overall goal is about using this medicine for children with heart failure, this taste study is an early step. You wouldn't be joining the study if you have heart failure yourself, as the focus here is purely on taste in healthy individuals.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you a man?
Are you between 18 and 45 years old?
Are you generally healthy?
Are you willing to try a liquid medicine and describe its taste?

Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, you would be asked to try a liquid version of the medicine called Vericiguat. The study focuses purely on tasting the medicine, so it's likely you would attend a research clinic for one or more visits. During these visits, you would be given a small amount of the liquid medicine to taste, and you would be asked to describe what it tastes like. The researchers might ask you specific questions about sweetness, bitterness, or any other flavours. They would also monitor your health briefly to ensure you're feeling well after taking the medicine. The total number of visits and the overall duration of the study for each participant are not detailed, but for a taste study, it's usually relatively short.

Potential risks and benefits

Potential benefits of taking part in this study include contributing to medical knowledge that could help children with heart failure in the future. You would also receive careful medical monitoring during your participation. Potential risks could include experiencing side effects from the medicine, even if it's a small dose, or finding the taste unpleasant. All studies carry some risk, but this phase of research usually involves strict safety checks. You are always free to withdraw from the study at any time, for any reason, without it affecting your usual medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

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Unverified
Germany

Common questions

Why are healthy men taking part if the medicine is for children with heart failure?

This study is an early step to understand the taste of the medicine. Healthy adults can give reliable feedback on taste, which helps scientists develop forms of the medicine that children might find easier to take.

Will I be given the full dose of the heart failure medicine?

It's a taste study, so you would likely be given very small amounts of the liquid medicine, just enough to assess the taste. The focus is not on treating a condition.

Will I know exactly what flavour I am tasting?

You will be asked to describe the taste in your own words. The researchers want to know your honest opinion about how it tastes.

Do I get paid for taking part?

Payment for participation varies between studies. This information is usually discussed in detail if you are invited to learn more about the study.

What happens if the liquid medicine tastes really bad?

Your feedback, whether the taste is pleasant or unpleasant, is crucial for the researchers. This information helps them to potentially improve the taste for future use in children.