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French Register Of Patients With Hemopathy Eligible For CAR-T Cell Treatment (DESCAR-T)

This study is essentially a registry, which means it's collecting information about people in France who have blood cancers and are either already receiving or are suitable for a specific treatment called CAR-T cell therapy. CAR-T cell therapy is a highly specialised treatment where a patient's own immune cells are modified in a lab to better fight their cancer. The study is gathering both past information (from people who've already had the treatment since July 2018) and current information (from people newly considered for it). The main goal is to understand how this innovative treatment is being used and how patients are doing, which can help improve care for others in the future.

At a glance

Status
Recruiting
Sponsor
The Lymphoma Academic Research Organisation
Enrolment target
5,000
Start
19 Dec 2019
Estimated completion
19 Dec 2038

What is this study about?

This study is called DESCAR-T, which stands for the French Register Of Patients With Hemopathy Eligible For CAR-T Cell Treatment. Don't worry too much about the long name; it just means it's an official record-keeping system for people in France who have certain blood cancers and are suitable for CAR-T cell therapy.

Haematological cancers are cancers that affect the blood, bone marrow, and lymph nodes. CAR-T cell therapy is a very advanced type of treatment where doctors take some of your own immune cells, called T-cells, and change them in a laboratory. They 'train' these cells to recognise and attack your cancer cells more effectively. These specially trained cells are then put back into your body to fight the disease.

The main purpose of this registry is to collect a lot of information about patients who are considered for, or have already received, this CAR-T cell therapy. By bringing all this information together, doctors and researchers hope to get a clearer picture of how well CAR-T cell therapy is working in real-world situations, what kinds of patients benefit most, and any challenges that arise. This knowledge can help improve how this important treatment is given in the future.

Key takeaways

  • This study collects real-world information about CAR-T cell therapy in France.
  • It aims to improve understanding and future care for patients with blood cancers.
  • Participation involves sharing your medical information, not undergoing new treatments.
  • Your privacy is protected, and your consent is important.
  • You can choose not to participate or withdraw at any time without affecting your care.

Who may be eligible?

To be part of this study, you would need to be a patient in France who has a blood cancer for which CAR-T cell therapy is a possible treatment. This includes people who have already received CAR-T cell therapy since July 2018, or those who are about to receive it now. The decision for CAR-T treatment must have been made by a team of specialist doctors during a meeting called a 'multidisciplinary tumour board' (RCP).

It's also important that if you are alive, you either give your permission, or you don't object to your health information being collected and used for this study. If a patient is no longer with us, their past wishes about data use would be respected. This study focuses specifically on patients who have access to the French healthcare system and are registered for social security in France.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

  1. Do you have a blood cancer?
  2. Has a team of specialist doctors decided that CAR-T cell therapy is a possible treatment for you?
  3. Are you receiving your medical care in France?
  4. If you're alive, have you agreed to or not objected to your medical information being used for research?
Answer every question to see your result.

What does participation involve?

This study is a registry, so what you're doing is allowing your medical information to be collected. There are no extra hospital visits, assessments, or medications you'd need to take specifically for this study. The information collected comes from your standard medical care.

For patients who have already had CAR-T cell treatment since July 2018, their past medical records will be used. For those who are newly considered for CAR-T cell treatment, your medical information will be collected as you go through the process of diagnosis, treatment, and follow-up. The study just gathers data from your regular medical journey, rather than asking you to do anything extra. This means there's no set total duration for your participation; it just involves collecting your existing medical care details.

Potential risks and benefits

The main benefit of taking part in this registry is that your medical information will help doctors understand more about CAR-T cell therapy. This understanding can lead to better care for future patients. There are no direct medical benefits to you from simply having your information collected, and you won't receive any new treatments through this study. As your medical data is being collected, there is a very small risk to your privacy, but strict measures are in place to protect your information and keep it confidential. Remember, deciding whether or not your data is used is completely your choice, and you are free to withdraw your consent for your information to be used at any time without affecting your medical care.

Locations (36)

  • CHU d'Amiens - Hôpital Sud
    Verified postcode
    Amiens, France· Recruiting
  • CHU Angers
    Verified postcode
    Angers, France· Recruiting
  • CHRU Besançon - Hôpital Minjoz
    Verified postcode
    Besançon, France· Recruiting
  • CHU de Brest - Hôpital du Morvan
    Verified postcode
    Brest, France· Recruiting
  • Institut d'Hématologie de Basse Normandie
    Verified postcode
    Caen, France· Recruiting
  • CHU d'Estaing
    Verified postcode
    Clermont-Ferrand, France· Recruiting
  • APHP - Hôpital Henri Mondor
    Verified postcode
    Créteil, France· Recruiting
  • CHU de Dijon
    Verified postcode
    Dijon, France· Recruiting
  • CHU de Grenoble
    Verified postcode
    La Tronche, France· Recruiting
  • CHRU de Lille - Hôpital Claude Hurriez
    Verified postcode
    Lille, France· Recruiting
  • Hôpital Dupuytren
    Verified postcode
    Limoges, France· Recruiting
  • Centre Léon Bérard
    Verified postcode
    Lyon, France· Recruiting

Common questions

What exactly is CAR-T cell therapy?

It's a special cancer treatment where your own immune cells are taken, trained in a lab to fight your cancer better, and then put back into your body.

Do I have to do anything extra if I join this study?

No, this study just collects information from your regular medical care. You won't have any extra appointments, tests, or medicines because of it.

Will my personal information be kept private?

Yes, extreme care is taken to protect your privacy. Your data will be handled confidentially to ensure it's secure.

Can I decide not to have my information used?

Yes, it's completely your choice. You can say no, or withdraw your permission at any time, and it won't affect your treatment.

What is a 'multidisciplinary tumour board' (RCP)?

It's a meeting where a team of different specialist doctors discuss your case to decide the best treatment plan for your cancer.

How to find out more

Karine Danno

Always speak to your GP or specialist before deciding to take part in a study.

Interested in taking part?

Register your interest

Share your details and the research team for "French Register Of Patients With Hemopathy Eligible For CAR-…" will contact you if you may be eligible. Always speak to your GP before agreeing to take part.

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