Assess Efficacy and Safety of Durvalumab Alone or Combined With Bevacizumab in High Risk of Recurrence HCC Patients After Curative Treatment

To be considered for this study, you would need to have been recently diagnosed with hepatocellular carcinoma (HCC) and have successfully had your cancer removed, either through surgery or a procedure called ablation. Doctors would need to confirm that there's no cancer visible on your scans shortly before you start. Your general health, including how well your liver and other organs are working, would also be checked carefully. You would need to be well enough to carry out most of your daily activities without much difficulty.

There are also some reasons why you might not be able to join. For example, if you have certain rare types of liver cancer, or if scans show the cancer has already spread to other parts of your body. If you've had a problem with your brain due to liver disease in the last year, or if you have specific types of blood clots in your liver's blood vessels, this study wouldn't be suitable. Also, anyone waiting for a liver transplant or who has already received certain types of cancer treatment for HCC would not be able to take part.

If you decide to take part in this study, you would be assigned to one of three groups by chance, like flipping a coin. You wouldn't know which group you're in, and neither would your doctors, to ensure fair results. One group would receive durvalumab plus bevacizumab, another would receive durvalumab alone, and the third group would receive a placebo (dummy treatment).

Taking part would involve regular visits to the hospital for treatment and check-ups. During these visits, you'd have physical examinations, blood tests, and scans (like CT or MRI) to monitor your health and see how the treatment is working. The study drugs would likely be given as an infusion into a vein, usually at the hospital. You would also be asked about any side effects you experience. The total duration of your active treatment would be determined by the study design, and after that, you would have follow-up appointments to track your long-term health. The exact schedule of visits and tests would be fully explained to you before you agree to join.