BOXR1030 T Cells in Subjects With Advanced GPC3-Positive Solid Tumors

To join this study, you need to be between 18 and 80 years old and weigh at least 50 kilograms (about 7 stone 12 pounds).

Your cancer must be advanced, meaning it cannot be removed by surgery or has spread to other parts of your body, and it must have a specific marker called GPC3. You will need to provide a recent sample of your tumour for testing. Your doctors must also confirm that standard treatments haven't worked well for your cancer, or you can't tolerate them.

It's important that you are generally well enough to take part, with good health in your vital organs like your heart, kidneys, and lungs. If you have liver cancer, there are also specific health criteria based on your liver function.

If you decide to take part, the first step is to check if your tumour has the GPC3 marker and if you meet all other health requirements. If you do, blood will be taken to collect your immune cells, which will then be sent away to create the BOXR1030 treatment specifically for you.

Before you receive the BOXR1030 treatment, you will have about three days of chemotherapy. This helps prepare your body for the new cells. You will need to be admitted to the hospital for this chemotherapy. After the chemotherapy, you'll receive the BOXR1030 treatment and will need to stay in hospital for at least 10 days afterwards so doctors can closely monitor your health. For the first month after treatment, you'll need to live close enough to the hospital that you can get there within two hours.

For the first six months after treatment, you'll have frequent hospital visits – daily at first, then less often, to check your health, look for side effects, and see how the treatment is working. You'll also need to monitor your temperature and do some simple tests at home. After six months, you will enter a long-term follow-up period, with visits scheduled less often for up to 15 years, to continue monitoring your health and the treatment's long-term effects.