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Enrolling by invitationOBSERVATIONAL

Sanger Human Cell Atlasing Project

The Sanger Human Cell Atlasing Project is creating a detailed map of every type of human cell. Imagine an atlas, but instead of countries, it shows all the different cells in your body and what they do. Researchers want to understand the unique features of each cell, like their genetic activity and how they change over time or in different places. This is important because current methods often combine signals from many cells, missing tiny but important differences. By looking at individual cells very closely, using new advanced technologies, scientists hope to build a complete reference guide for human cells. This will help us understand health, disease, and eventually lead to better ways to diagnose, monitor, and treat illnesses.

At a glance

Status
Enrolling by invitation
Sponsor
The Wellcome Sanger Institute
Enrolment target
4,000
Start
16 Dec 2019
Estimated completion
07 Nov 2029

What is this study about?

This project is all about creating a super detailed map of every single cell type in the human body. Think of it like drawing a very precise blueprint of a house, but for cells. Every part of your body, from your skin to your brain, is made up of countless tiny cells, and they all have specific jobs. Scientists want to understand exactly what makes each type of cell unique – what genes are active, how they behave, and where they are located.

Why is this important? Well, imagine trying to understand a whole choir by only listening to all the voices blended together. You'd miss the individual singers and what makes them special. In the same way, older scientific methods often looked at millions of cells at once, hiding important details about individual cells. These individual differences can be key to how our bodies stay healthy or how diseases start and get worse. By looking at cells one by one, using clever new technologies, researchers can see these tiny but crucial details.

The goal is to build a complete reference guide – a 'cell atlas' – that shows all the different kinds of human cells. This map will be a fundamental tool for future medical discoveries. It will help scientists understand how our bodies work normally, where things go wrong in diseases, and ultimately lead to new and better ways to diagnose problems, keep track of them, and find effective treatments for a wide range of illnesses.

Key takeaways

  • A major project to map every human cell type.
  • Aims to understand health and disease better.
  • Will lead to new ways to diagnose and treat illnesses.
  • Uses advanced technology to study individual cells.
  • Samples from all ages, healthy or sick, are needed with consent.

Who may be eligible?

This study is looking for samples from a wide range of people, both living and deceased, and from all ages (from newborns to people over 99). Samples can come from healthy individuals or those with a disease.

However, it's very important that all samples have been given with full permission for research use. If a sample was taken historically without proper consent for future research, or if the individual was not able to understand and give consent themselves, then those samples cannot be used in this project.

Basically, if you or a loved one provides a sample (like blood or tissue) and you fully understand and agree for it to be used for research, it's likely to be suitable. The study includes both male and female participants.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

  1. Are you, or the person whose sample is being considered, any age?
  2. Is the sample from a healthy person or someone with a disease?
  3. Was full permission (consent) given for your sample to be used in research?
  4. Are you able to understand and give consent for the use of your sample?
  5. Are you male or female?
Answer every question to see your result.

What does participation involve?

If you were to take part in this project, it would involve providing a sample, such as blood or tissue. The study itself doesn't involve ongoing visits or assessments. You wouldn't be given any medication as part of this research. It's about collecting biological samples to analyse at a cellular level, rather than testing new treatments or monitoring your health directly. The collection of your sample would be a one-off event. There is no long-term follow-up required from you once your sample is provided and processed.

Potential risks and benefits

The main benefit of contributing to this research is helping to build a foundational map of human cells, which could lead to significant advancements in understanding and treating many diseases in the future. There are no direct personal health benefits to you for participating, as this is laboratory research on samples. The risks associated with participation are generally minimal, primarily related to the procedure of collecting the sample itself (e.g., discomfort from a blood draw, or risks associated with a biopsy if that's how the tissue sample is obtained), which would be fully explained beforehand. You would always have the right to withdraw your consent for your sample to be used in the research at any point.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.
  • Wellcome Sanger Institute
    Verified postcode
    Cambridge, United Kingdom

Common questions

What is a 'cell atlas'?

It's like a detailed map that shows all the different types of cells in the human body, what they do, and where they are located.

Why do we need this cell map?

It will help scientists better understand how our bodies work when healthy and what goes wrong when we get sick, leading to new ways to treat diseases.

Who can provide samples for this project?

Samples are needed from people of all ages, both healthy and those with illnesses, always with full permission (consent).

Does taking part involve frequent hospital visits?

No, taking part in this specific study usually just involves providing a sample once. There are no follow-up visits or treatments.

Will this research help me directly?

This study aims to benefit future medicine for everyone, rather than providing direct personal health benefits to those who provide samples.

How to find out more

Always speak to your GP or specialist before deciding to take part in a study.

Interested in taking part?

Register your interest

Share your details and the research team for "Sanger Human Cell Atlasing Project…" will contact you if you may be eligible. Always speak to your GP before agreeing to take part.

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