Characterization of Bacterial and Mycosis Skin Flora in Seborrheic Macular Hypopigmentation - Microbiome
This research is investigating a skin condition called Seborrheic Macular Hypopigmentation (SMH). This condition causes light-coloured, oval-shaped patches, mostly on the face and body of people with darker skin. Doctors have noticed that it was previously confused with vitiligo, but it is actually a different condition. At the moment, nobody knows what causes SMH, which makes it hard to treat effectively. This study aims to find out more by looking closely at the different types of bacteria and fungi (known as the microbiome) on these light patches, and comparing them to healthy skin on the same person, as well as to the skin of healthy volunteers. The goal is to understand the cause of SMH better, which could lead to better treatments in the future.
At a glance
What is this study about?
Imagine getting lighter patches on your skin, especially on your face and body. This is what happens in a skin condition called Seborrheic Macular Hypopigmentation, or SMH for short. It's most commonly seen in people with darker skin tones. For a while, doctors thought these patches might be a type of vitiligo, but we now know it's a separate condition.
The tricky thing about SMH is that we don't yet understand what causes it. This makes it really hard to find good treatments that work. That's why this study is so important: it's trying to get to the root of the problem.
In this research, scientists will be looking at tiny living things like bacteria and fungi that live on our skin – this is called our skin microbiome. They will compare the microbiome on the light patches of people with SMH to the microbiome on their healthy skin nearby, and also to the skin of people who don't have SMH. By doing this, they hope to discover if certain bacteria or fungi play a role in causing SMH. Understanding the cause is the first big step towards developing effective treatments for this disfiguring skin condition.
Key takeaways
- This study aims to find the cause of Seborrheic Macular Hypopigmentation (SMH).
- SMH causes light skin patches, mainly on the face and body.
- Researchers will study bacteria and fungi on the skin.
- Understanding the cause could lead to new treatments.
- Participation involves skin samples, not direct treatment.
- Both SMH patients and healthy volunteers are needed.
Who may be eligible?
This study is looking for adults aged 18 or over. You need to have been diagnosed with Seborrheic Macular Hypopigmentation (SMH) and have patches on your face. You also need to be able to understand the study information and give your permission to take part, and be able to attend appointments.
There are some reasons why you wouldn't be able to join. If you've taken certain antibiotics or antifungal medicines in the past few weeks, or used creams for similar purposes on your face recently, you wouldn't be eligible. Also, if you've had certain cosmetic treatments on your face like laser, radiofrequency, or chemical peels in the last three months, you can't take part.
Finally, if you are pregnant, breastfeeding, under 18, or unable to give your own consent for any reason, you won't be able to join this particular study.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- Are you 18 years old or older?
- Have you been diagnosed with SMH and have patches on your face?
- Have you avoided systemic antibiotics or antifungals in the last 4 weeks?
- Have you avoided topical antibiotics or antifungals on your face in the last 2 weeks?
- Are you able to give your informed consent?
- Are you not pregnant or breastfeeding?
What does participation involve?
The study does not specify the number of visits, duration, or whether there will be follow-up. However, it will involve assessments to confirm your diagnosis, and samples will be taken from your skin. This will likely include samples from the lighter patches of skin on your face and also from some normal skin nearby. If you are a healthy volunteer, samples will be taken from your skin too. The study will not involve any medication directly for your SMH, as its purpose is to understand the condition, not to treat it during the trial.
Potential risks and benefits
Locations (3)
- CHU de Nice - Hôpital de l'ArchetVerified postcodeNice, France· Recruiting
- Hôpital Louis Pasteur, hôpitaux Civils de ColmarVerified postcodeColmar, France· Recruiting
- Hôpital Saint-Louis - APHPVerified postcodeParis, France· Recruiting
Common questions
What is Seborrheic Macular Hypopigmentation (SMH)?
It's a skin condition where you get lighter, oval-shaped patches, often on the face and body, especially if you have darker skin. Doctors are still learning about it.
Is SMH the same as vitiligo?
No, while it might look similar, current research suggests it's a distinct condition from vitiligo.
What is a 'skin microbiome'?
It's all the tiny bacteria, fungi, and other microorganisms that naturally live on the surface of your skin.
Will taking part in this study treat my SMH?
No, the study's main goal is to understand the causes of SMH, not to treat it. However, the findings could help develop future treatments.
Do I need to be a patient to join?
The study is looking for both individuals with SMH and healthy volunteers who do not have the condition.
How to find out more
Thierry Passeron, PhD
Always speak to your GP or specialist before deciding to take part in a study.
Interested in taking part?
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