Venous Stenting Evaluation in Patients With Intracranial Hypertension Under Long-term Acetazolamide

To join this study, you need to be at least 18 years old and have a clear diagnosis of Idiopathic Intracranial Hypertension (IIH). You should have been taking acetazolamide medication for your IIH for over a year, but still be experiencing issues such as bothersome side effects or your symptoms aren't well controlled. We'll also check if you have a specific type of narrowing in a brain vein (called the transverse sinus) that shows up on an MRI scan, as this is what the stent would target.

There are also some reasons why you might not be able to join. For example, if you've recently taken certain other medications (like topiramate) or substances that can affect brain pressure. We also can't include you if you've previously had a blood clot or a tumour in your brain. People with severe vision loss, certain eye conditions, or who are pregnant would also not be able to take part. It's important to be generally healthy enough to attend all study appointments and undergo the procedures involved.

If you decide to join this study, you'll first be assessed to make sure you meet all the requirements. You'll then be randomly placed into one of two groups: one group will continue with standard medical care, which includes your recommended medication and advice on weight loss; the other group will receive the stent procedure in addition to this standard medical care. The stent will be placed in a specific vein in your brain.

Regardless of which group you're in, you'll have specific follow-up appointments scheduled at 1 month, 3 months, and 12 months after starting the study. These visits will involve various checks and tests to see how you're responding and to monitor any changes in your symptoms and brain pressure. You'll need to be available to attend all these scheduled visits over the course of the year-long study.