Study to Evaluate the Efficacy and Safety of Oral Rilzabrutinib in Adults With Immune Thrombocytopenia (ITP) Who Failed First-line Treatment

This study is looking for adult men and women, aged 18 and over, who have been diagnosed with a specific type of ITP called 'primary ITP.' You might be a good fit if you've already tried at least one initial treatment for your ITP, and while that treatment might have helped at first, it's no longer working as well, or you've had to continue taking steroids to manage your condition.

However, there are certain situations that would mean you couldn't join this study. For example, if your ITP is caused by another underlying health problem (we call this 'secondary ITP'), or if you've had certain other conditions like some types of cancer in recent years, or if you've had an organ transplant. People who have already had advanced treatments for ITP or had their spleen removed for ITP reasons would also not be able to participate.

Also, if you are pregnant or breastfeeding, this study would not be suitable for you.

If you join this study, your journey would typically begin with a 'screening period' lasting up to 8 weeks. During this time, the study team will carry out various tests and checks to make sure the study is right for you. If you are eligible, you would then enter the 'primary analysis period,' which lasts for up to 28 weeks. During this time, you would take the study medicine, rilzabrutinib, as directed, and attend regular appointments for assessments and to monitor your health. Some participants might then be invited to continue in a longer 'extension period' for another 28 weeks. After finishing the treatment part of the study, there will be a 'follow-up period' for about 24 weeks, where the study team will check on your health and well-being. The total length of your involvement could vary depending on which parts of the study you participate in.