AuthorisedTherapeutic use (Phase IV)Interventional

ANTIMIDIS - Cefazolin mediastinal distribution using microdialysis

This study, called ANTIMIDIS, is investigating how an antibiotic named cefazolin moves into the area surrounding your heart and lungs, known as the mediastinum. Doctors often give cefazolin to patients to prevent infections, especially after operations. The main goal is to understand how well and how quickly this antibiotic gets to the infection site. By carefully measuring its levels, researchers hope to find the best way to give cefazolin to ensure it works effectively to stop bacteria from causing problems. This knowledge can help doctors provide the right dose to protect patients from serious infections.

At a glance

Status

Authorised

Phase

Therapeutic use (Phase IV)

Sponsor

Assistance Publique Hopitaux De Paris

Enrolment target

Start

05 Jun 2026

Infection prophylaxis

What is this study about?

Imagine you have an operation, and doctors want to give you an antibiotic to stop an infection from starting, especially around your heart and lungs. This study is all about understanding how one specific antibiotic, called cefazolin, gets into that area, which medical experts call the 'mediastinum'. Think of it like trying to get water into a specific part of a garden – this study helps us understand how quickly and how much water (cefazolin) actually reaches the right spot.

The main aim is to work out the best way to give this antibiotic so it can do its job properly. When doctors give medicine, they want to make sure enough of it reaches the target area to kill any harmful bacteria, but without giving too much. This study uses special measurements to track the cefazolin, helping researchers understand how an individual's body handles the medicine and what the ideal dose might be.

Why does this matter? By figuring out the best way to use cefazolin, doctors can improve how they prevent infections. This could mean fewer patients get infections after surgery, leading to better recovery and shorter hospital stays. It's about making sure that when you're given an antibiotic to protect you, it's working as effectively as possible.

Key takeaways

Studies how a common antibiotic (cefazolin) works to prevent infection.
Aims to find the best way to use cefazolin for powerful protection.
Involves placing a tiny temporary probe during surgery.
Open to adults of all ages and genders needing this antibiotic.
Could help improve infection prevention for future patients.

Who may be eligible?

Anyone can potentially take part in this study, regardless of their age or gender. The study is open to both men and women, and there are no age limits mentioned, meaning adults of any age might be considered.

Generally, participants would be people who are already having surgery where they would be given cefazolin for infection prevention. This study isn't about testing a new drug for the first time, but rather about understanding how a drug already in use works in the body.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Am I having surgery where I would typically receive cefazolin for infection prevention?
Am I open to having a small probe temporarily placed during my operation?
Am I comfortable with researchers collecting follow-up information about my recovery for a few weeks?
Do I understand that this study is about understanding an existing medicine, not testing a new one?

Answer every question to see your result.

What does participation involve?

If you take part in this study, you won't be given a new or experimental drug; it's about understanding an antibiotic that's already used. A small, very thin probe (like a tiny tube) would be placed near your heart during your surgery. This probe is used to gently collect tiny samples of fluid from the area around your heart and lungs, allowing researchers to measure the levels of cefazolin there. This helps them see how quickly and effectively the antibiotic is reaching the right place.

This monitoring happens while you are recovering from your surgery. Your doctors will continue to look after you as usual. After the monitoring period, the probe will be carefully removed. Researchers will also collect information about your recovery for about a month after the probe is taken out, like whether you had any infections, what other medicines you received, and how your body was fighting inflammation. The total duration of active measurement is short, usually during and immediately after your surgery, with follow-up information collected about your recovery for a few weeks.

Potential risks and benefits

Participating in this study might offer the benefit of contributing to better understanding and use of antibiotics for future patients, potentially leading to improved infection prevention. However, there are potential risks, such as those typically associated with having a small probe inserted temporarily during surgery, although doctors take great care to minimise these. It's important to remember that you have the right to withdraw from the study at any time, for any reason, without it affecting your medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

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Unverified
France

Common questions

What is the main purpose of this study?

To understand how an antibiotic called cefazolin spreads around the heart and lungs to prevent infections, so doctors can use it more effectively.

Will I be given a new or experimental medicine?

No, this study looks at an antibiotic (cefazolin) that is already routinely used to prevent infections after surgery.

What will happen during the study?

A small probe will be placed near your heart during surgery to measure antibiotic levels. Researchers will also follow your recovery for a few weeks.

Does taking part affect my medical care?

No, your medical care will be managed as usual by your doctors, independent of your participation in the study.

Can I change my mind about participating?

Yes, you are free to withdraw from the study at any time without it affecting your treatment or care.