AuthorisedHuman Pharmacology (Phase I)- OtherInterventional

Relative bioavailability and effect of food study with GLPG3667 in healthy subjects

This study, called "Relative bioavailability and effect of food study with GLPG3667 in healthy subjects," is testing a new medicine called GLPG3667. This medicine is designed for people with inflammatory and autoimmune diseases, which are conditions where your body's defence system mistakenly attacks healthy tissues. The main goal of this particular study is to understand how much of the medicine the body takes in and uses (this is called bioavailability). Researchers also want to find out if eating food affects how the body absorbs the medicine. This helps them work out the best way for people to take the medicine in the future. It’s an early stage study, for healthy adults to help gather important information.

At a glance

Status

Authorised

Phase

Human Pharmacology (Phase I)- Other

Sponsor

Galapagos

Enrolment target

Start

27 Apr 2026

inflammatory and autoimmune diseases

What is this study about?

This study is an early research stage for a new medicine named GLPG3667. This medicine is being developed for people who suffer from inflammatory and autoimmune diseases. These are conditions where your body's immune system, which normally fights off infections, starts to attack healthy parts of your own body by mistake. Examples include conditions like rheumatoid arthritis or lupus, although this study does not involve patients with these conditions directly.

The main purpose of this study is to understand how the human body handles GLPG3667. Specifically, researchers want to see how much of the medicine gets into your bloodstream and how quickly. This is crucial for working out the right dose and how often people might need to take it in the future. They also want to check if eating food before or after taking the medicine makes a difference to how it's absorbed. Finding this out helps ensure the medicine will work as effectively as possible for patients.

This type of study is called a 'Phase I' study, which means it’s one of the first times the medicine is being tested in people. It’s important to do these early studies to make sure the medicine is safe and to gather vital information about how it works in the body before it can be tested in people who actually have the conditions it aims to treat.

Key takeaways

This study is testing a new medicine called GLPG3667.
It's for people with inflammatory and autoimmune diseases.
The study checks how the body absorbs the medicine and if food makes a difference.
Only healthy adults aged 18 and over can join.
Participation involves clinic visits, taking the medicine, and health checks.
It's an early-stage study to gather important information for future patients.

Who may be eligible?

This study is looking for healthy adults to take part. This means you should generally be in good health and not have any serious ongoing medical conditions. The study is open to anyone aged 18 years or older, and there's no upper age limit.

Both men and women can participate in this study. The medical team will check your health carefully to make sure taking part is safe for you. They will look at things like your medical history, any medicines you currently take, and perform some basic health checks.

Because this is an early study to understand how the medicine works in healthy people, you won't be eligible if you already have one of the inflammatory or autoimmune diseases that GLPG3667 is designed to treat. The aim here is to see how the medicine behaves without being affected by an existing illness.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Do you consider yourself generally healthy?
Do you NOT have a diagnosed inflammatory or autoimmune disease?
Are you willing to attend clinic visits and potentially stay overnight?
Are you able to follow specific instructions about taking medicine and food?

Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, you might need to come to the study clinic for several visits. Some of these visits might involve staying overnight, or even for a few days, so the doctors can closely monitor how your body reacts to the medicine. During these stays, you would receive the new medicine, GLPG3667. You would be given specific instructions on how and when to take it, and whether to take it with or without food for different parts of the study.

Throughout the study, the research team will perform various assessments. This includes regular blood tests to check how much of the medicine is in your system and how your body is responding. They might also check your blood pressure, heart rate, and ask you about how you are feeling. After you've finished taking the medicine, there might be some follow-up appointments to make sure you remain well. The total time you would be involved in the study can vary, and the study team will explain the full schedule to you in detail.

Potential risks and benefits

Participating in a study like this helps researchers learn important information about new medicines that could eventually help many people with serious conditions. You wouldn't directly benefit from this medicine as it's designed for people with specific illnesses, and you are expected to be healthy. However, you would receive careful medical attention and health checks throughout the study. Every medical study carries some potential risks; you might experience side effects from the medicine, or discomfort from procedures like blood tests. All known potential risks will be fully explained to you before you agree to take part. Remember, you can also choose to leave the study at any time, for any reason, without it affecting your medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

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Unverified
Belgium

Common questions

What is GLPG3667?

GLPG3667 is a new medicine being developed to help people with inflammatory and autoimmune diseases, where the body's immune system attacks itself.

Why is this study done in healthy people if the medicine is for sick people?

This early study helps researchers understand how the medicine works in the body and if it's safe before giving it to people who are unwell. This helps them find the right dose.

Will I get paid to take part?

Payment for participation varies between studies. The study team will be able to tell you if you will be reimbursed for your time or travel expenses.

What happens during the study visits?

You'll have health checks, might need to stay overnight, take the study medicine, and have blood tests to see how your body reacts.

Can I stop participating if I change my mind?

Yes, you can choose to leave the study at any time, for any reason, without having to explain why, and it won't affect your future medical care.