Phase II Randomized Clinical Trial of quinacrine versus metronidazole in resistant giardiasis in children: Quin4Kids
This study, named 'Quin4Kids', is a research project focused on finding better treatments for a common tummy bug called giardiasis, especially when it's hard to get rid of with usual medicines. It's comparing two different medications: quinacrine and metronidazole. Researchers want to see which medicine is more effective at clearing up the giardia infection in children. They will also look at how much of the medicine stays in the body, how well children tolerate the treatments, and if there are any side effects. The aim is to make sure children get the best possible care for this condition, particularly if their infection has been resistant to other treatments in the past. This will help doctors understand more about giardiasis and how to treat it effectively in young people.
At a glance
What is this study about?
This study, called 'Quin4Kids', is all about helping children who have a tummy infection called giardiasis. Giardiasis is caused by a tiny bug called Giardia intestinalis, and it can cause symptoms like tummy aches, diarrhoea, and feeling sick. Most of the time, this infection can be treated with medicines. However, sometimes the bug can be a bit stubborn and not go away with the usual treatments. This is what we mean by "resistant giardiasis."
The purpose of this research is to compare two different medicines: quinacrine and metronidazole. Researchers want to find out which one is better at getting rid of the giardia bug in children, especially when the infection hasn't responded to previous treatments. By doing this, they hope to improve how doctors treat giardiasis in children who are not getting better with standard medicines. They will carefully check if the giardia bug is completely gone after treatment.
Apart from seeing which medicine works best, the study will also look at other important things. They'll measure how much of the medicine gets into the body and how long it stays there, which is important for understanding how well a medicine works in children. They will also keep a close eye on any side effects and how well the children tolerate the medicines. This information will help develop better versions of the medicine, specifically designed for children, in the future. The ultimate goal is to find safe and effective ways to help children with giardiasis feel better and get rid of the infection for good.
Key takeaways
- Tests two different medicines for a stubborn tummy bug (giardiasis) in children.
- Aims to find which medicine works better at clearing the infection.
- Will track medicine levels in the body and look for side effects.
- Hopes to improve future treatments for children with resistant giardiasis.
- Participation is voluntary and you can withdraw at any time.
Who may be eligible?
This study is looking for children to take part. Children of any age can be considered, from babies to teenagers. Both boys and girls are welcome.
The main thing is that your child needs to have giardiasis, which is a tummy bug, and it needs to be stubborn or "resistant," meaning it hasn't gone away with other treatments.
A doctor involved in the study will check if your child is suitable and meets all the specific requirements to join. They will make sure it's the right study for your child.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- Does your child have giardiasis?
- Has your child's giardiasis been difficult to treat with previous medicines?
- Is your child any age (babies to teenagers)?
- Are you able to attend study visits?
What does participation involve?
If your child takes part in this study, they will receive either quinacrine or metronidazole, which are both medicines used to treat giardiasis. The doctors and nurses will explain exactly how to give these medicines.
Your child will have a number of visits to the clinic so that doctors can check on their health, see how they are responding to the medication, and look for any side effects. These visits will involve various checks, which might include stool (poo) samples to see if the giardia bug has gone, and sometimes blood or hair samples to measure how much of the medicine is in their body.
There will also be follow-up appointments after the treatment has finished to make sure the infection hasn't come back and that your child remains well. The total time your child will be involved in the study, including treatment and follow-up, will be explained by the study team, but it is designed to be manageable for families.
Potential risks and benefits
Locations (1)
- —UnverifiedSpain
Common questions
What is giardiasis?
Giardiasis is an infection in the gut caused by a tiny parasite, which can lead to tummy aches, diarrhoea, and feeling unwell.
Why is this study called 'Quin4Kids'?
It's a short name for 'Quinacrine for Kids', comparing quinacrine with another medicine to treat giardiasis in children.
Will my child definitely get better if they join the study?
While the study aims to find better treatments, no treatment can guarantee a cure. Doctors will monitor closely to give your child the best care.
What kind of medicines are being tested?
The study is comparing two existing medicines: quinacrine and metronidazole, to see which is more effective for resistant giardiasis.
What happens if my child has side effects?
The study team will carefully watch for any side effects and will provide support and medical care if needed.
How to find out more
Always speak to your GP or specialist before deciding to take part in a study.
Discussion
Community discussion
Powered by our forum at community.patient.info. Please be respectful — this is not medical advice.