AuthorisedTherapeutic use (Phase IV)Interventional

Antimicrobial treatment of laryngeal leukoplakia

This study is investigating how effective certain widely used medications are at treating a condition called laryngeal leukoplakia. This condition involves white patches forming in your voice box (larynx). The main goal is to see if these medicines can make these patches go away. Participants will receive either Diflucan (an antifungal medicine) or Keflex (an antibiotic). This research is for adults of all genders and is a later-stage study, meaning the medicines are already approved for other uses. If you have been diagnosed with laryngeal leukoplakia, this study aims to find the best way to help clear up these patches.

At a glance

Status

Authorised

Phase

Therapeutic use (Phase IV)

Sponsor

HUS-Yhtymae

Enrolment target

Start

30 Oct 2024

laryngeal leukoplakia

What is this study about?

This study is about a condition called laryngeal leukoplakia. This is when white patches appear on your voice box, which is the part of your throat that helps you speak. Sometimes, these patches can be a sign of other problems, so doctors often keep a close eye on them. The good news is that this study is trying to find effective ways to treat these patches and make them disappear.

The researchers are testing two different medicines that are already used for other common health issues. One is called Diflucan, which is often used to treat fungal infections. The other is Keflex, which is an antibiotic used to fight bacterial infections. The study aims to see which of these, if either, is best at clearing up the white patches of laryngeal leukoplakia. They are specifically looking for the complete disappearance of these patches after treatment.

This type of study is often called 'Phase IV' research. This means the medicines being tested are already approved and regularly used by doctors for other conditions. The purpose here is to understand more about their effectiveness and safety when used for laryngeal leukoplakia. By taking part, you could help doctors learn more about the best ways to treat this condition for many people in the future.

Key takeaways

Tests existing medicines for white patches in the voice box (laryngeal leukoplakia).
Aims to make these white patches disappear.
For adults aged 18 and over, of all genders.
Medicines are Diflucan (antifungal) and Keflex (antibiotic).
Participation includes taking medicine and having regular check-ups.
You can stop participating at any time.

Who may be eligible?

To join this study, you need to be an adult, 18 years old or older. There is no upper age limit, so people of all adult ages can take part. Both men and women are welcome.

The most important requirement is that you must have been diagnosed with laryngeal leukoplakia, which means you have those white patches in your voice box that the study is trying to treat.

Further specific health details would be checked by the study doctors to make sure the treatment is safe and suitable for you. This might include checking other medical conditions you have or any other medicines you are currently taking.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Have you been diagnosed with laryngeal leukoplakia?
Are you able to attend regular appointments?
Are you comfortable taking study medication?
Are you generally in good health, apart from your laryngeal leukoplakia?

Answer every question to see your result.

What does participation involve?

If you decide to take part, you would be given one of the study medicines, either Diflucan or Keflex. The doctors would decide which one is best for you, and you would take these medicines as prescribed. The aim is for the white patches in your voice box to disappear.

You would have regular appointments with the study doctors. During these visits, they would check your progress and see how the treatment is working. This might involve looking at your voice box to see if the patches are shrinking or gone. They would also ask about any side effects you might be experiencing.

The total length of time you'd be involved in the study would depend on how long it takes for the treatment to work and for doctors to confirm the patches have disappeared, along with any necessary follow-up checks. All visits, medicines, and assessments directly related to the study would be provided and would not cost you anything.

Potential risks and benefits

Taking part in this study could potentially be beneficial if the medicines help clear up your laryngeal leukoplakia. You would also be closely monitored by medical professionals. However, like all medicines, Diflucan and Keflex can have side effects, which your doctor will discuss with you. There's also no guarantee that the treatment will work for everyone. You are free to stop participating in the study at any time, for any reason, without it affecting your usual medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

—
Unverified
Finland

Common questions

What is laryngeal leukoplakia?

It's a condition where white patches appear on your voice box (larynx).

What medicines are being tested?

The study is testing Diflucan (an antifungal) and Keflex (an antibiotic).

Who can join the study?

Adults aged 18 and over, of any gender, who have laryngeal leukoplakia.

Will I have to pay for anything?

No, all study-related medicines and appointments are provided free of charge.

Can I leave the study if I change my mind?

Yes, you can withdraw from the study at any time, for any reason.

How to find out more

Official trial record

Always speak to your GP or specialist before deciding to take part in a study.