RecruitingNAINTERVENTIONAL

Evaluation of Left Ventricular Ejection Fraction Using an Accelerated Cardiac Cine-MRI Sequence With Deep Learning-based Image Reconstructions

This study is investigating a new, faster type of MRI scan for the heart. It's especially for people with conditions like a thick heart wall, which can be caused by high blood pressure or other issues. The usual heart MRI scans require patients to hold their breath many times, which can be difficult, especially for older or breathless individuals. This new scan uses special computer technology to get clear pictures more quickly. Researchers want to find out if this quicker scan can accurately measure how well the heart is pumping, just like the standard scan. If it works, it could make heart MRI scans more comfortable and shorter for patients.

At a glance

Status

Recruiting

Phase

Sponsor

Centre Hospitalier Universitaire, Amiens

Enrolment target

Start

05 Aug 2025

Estimated completion

01 Sep 2026

Left Ventricular Ejection Fraction Cardiac Magnetic Resonance Imaging Deep Learning Image Reconstruction Left Ventricular Hypertrophy

What is this study about?

Imagine your heart as a powerful pump. Sometimes, its main pumping chamber, called the left ventricle, can become too thick – doctors call this 'left ventricular hypertrophy' or LVH. This can happen for various reasons, like high blood pressure or certain heart conditions. To understand how well your heart is working and to guide treatment, doctors often use special scans.

The most detailed and accurate scan for this is usually a heart MRI. This scan gives doctors a very clear picture of your heart's structure and how effectively it's pumping blood. However, the traditional heart MRI can be quite long. It often requires you to hold your breath repeatedly for short periods, which can be challenging and uncomfortable, particularly if you're elderly or find it hard to breathe.

This study is exploring a new, quicker way to do these heart MRI scans. It uses advanced computer technology, sometimes called 'deep learning', to speed up the process while still getting high-quality images. The main aim is to see if this faster scan provides the same accurate information about your heart's pumping ability as the standard, longer scan. If it does, it could mean shorter, more comfortable MRI appointments for patients in the future.

Key takeaways

This study tests a new, quicker heart MRI scan.
It's for people with a thickened heart wall.
The new scan uses clever computer technology.
Aims to make MRI scans faster and more comfortable.
The goal is to provide equally accurate results.
Could improve future heart scans for everyone.

Who may be eligible?

This study is looking for people aged 18 or over who are having a heart MRI scan because they have, or are being checked for, a thickened heart wall. You must be able to understand and agree to take part, and be part of the UK's social security scheme.

However, there are some reasons why you might not be able to join. For example, if you are pregnant or breastfeeding, or if you have a severe fear of enclosed spaces (claustrophobia). You also can't take part if you have certain medical conditions or devices that prevent you from having an MRI, like some types of pacemakers or metal implants. People with known allergies to certain dyes used in MRIs or those who find it very hard to hold their breath for even short periods also won't be able to participate. This study also isn't suitable if you are very overweight (over 140kg) as you might not fit in the scanner.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Are you having a heart MRI for a thickened heart wall?
Can you understand and agree to take part?
Do you fit safely inside an MRI scanner?
Do you have any metal in your body that prevents an MRI?

Answer every question to see your result.

What does participation involve?

This study involves having a particular type of accelerated heart MRI scan. You would undergo this scan as part of your regular assessment or follow-up for a thickened heart wall condition. The process will be similar to a standard MRI, but the scanning part might be quicker. There are no extra visits or medications involved beyond what you would usually have for an MRI. The total duration of your involvement would be the time it takes to complete the MRI scan session.

Potential risks and benefits

Taking part in this study could mean you contribute to developing a faster, more comfortable heart MRI scan for future patients, which is a potential benefit for healthcare. Since you'll be having a heart MRI as part of your usual care, this study adds an alternative way of getting the scan done. The risks are generally the same as those for a standard MRI scan, which will be explained to you in detail. These can include allergic reactions to the contrast dye (if used) or discomfort from the scanner noise or lying still. You are free to withdraw from the study at any time, for any reason, without it affecting your medical care.

Locations (1)

CHRU Amiens
Verified postcode
Amiens, France· Recruiting

Common questions

What is a 'thick heart wall'?

It means the muscle of the heart's main pumping chamber has become thicker than usual, which can affect how well it works.

What is Deep Learning?

It's a type of advanced computer technology that helps process images quickly and effectively, making faster scans possible.

Will I have to hold my breath during this faster scan?

The goal of this new scan is to reduce the need for long breath-holds, making it potentially easier for you.

Is the new scan safe?

Yes, it uses the same MRI technology as standard scans, but with different computer settings to speed things up. All MRI safety precautions still apply.

Will my doctors use the results of this study scan for my treatment?

The study aims to see if this new scan is as good as the old one. Your doctors will discuss your individual results and treatment plans with you.

How to find out more

Cédric Renard, MD

renard.cedric@chu-amiens.fr 33+3 22 08 75 37 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.