Evaluation of the Benefits of Administering Immunosuppressive Drugs as Single Daily Doses Over the First Year After Liver Transplantation (EASY)

This study is looking for adults who have recently had their very first liver transplant from a deceased donor. You would need to have had your transplant less than four weeks before joining the study.

There are also some reasons why you might not be able to join. For example, if you received only part of a liver, or if you had any other organ transplanted at the same time as your liver. You also can't join if you have certain other serious health problems, are taking specific medicines that might interfere with the study drugs, or are pregnant or breastfeeding.

Finally, to join, you must be able to understand what the study involves and agree to take part by signing a consent form. You also need to be willing to follow the study plan and attend all visits.

If you join this study, you will be assigned to one of four groups, each taking a slightly different combination and timing of your anti-rejection medicines (tacrolimus and mycophenolate mofetil). Some groups will take both medicines once a day, and others will take one once a day and the other twice a day. All participants will take their medicines for the first year after their transplant.

You will have regular check-ups at the hospital, which will involve blood tests to monitor your medicine levels and overall health. Some of these blood tests might involve using a special device at home, which allows you to take small blood samples yourself, meaning fewer trips to the hospital. You will also be asked to answer questions about your quality of life and how easy you find it to take your medicines. The study will last for the first year after your liver transplant.