RecruitingOBSERVATIONAL

Prospective Multicenter Research on Donor and Recipient Management Strategies to Improve Lung Transplant Outcomes

This project aims to understand how different choices made about organ donors and medical care can improve the success of lung transplants. Researchers will gather detailed health information, blood samples, and patient experiences from 2,600 people involved in lung transplantation. This includes those waiting for a new lung, the donors, and the people who have received a transplant. The information collected will help create a valuable resource for future research. Scientists hope to discover how different medical practices affect how well patients do after a transplant and identify early signs in the blood that could predict problems like infection, rejection, or other complications. Ultimately, this research strives to find better ways to manage lung transplants at every stage, from finding a donor to long-term recovery.

At a glance

Status

Recruiting

Sponsor

Duke University

Enrolment target

2,600

Start

03 Sep 2024

Estimated completion

30 Jun 2027

Lung Transplant; Complications Lung Transplant; Infection or Inflammation Lung Transplant Rejection Lung Transplant Failure

What is this study about?

Imagine a big research effort focused on making lung transplants work even better for patients in the UK. That's what this study is all about. It's not a study where you get new medicines or treatments; instead, it's about carefully watching and learning from what's already happening.

Researchers will collect a lot of information from 2,600 people who are either waiting for a lung transplant, have donated lungs, or have recently received a lung transplant. This includes details about their health, medical care, and how they feel. They'll also collect blood samples. By gathering all this information, scientists can build a huge picture of how lung transplants are managed across different hospitals.

The main goal is to figure out what factors lead to the best results for patients, and what might contribute to problems like infections, rejection (when the body tries to fight off the new lung), or failure of the transplant. For example, they want to see if different ways of looking after donors or different medical practices after the transplant change how well people recover. They also want to identify markers in the blood that could warn doctors about potential issues before they become serious.

Key takeaways

This study collects health information and blood samples to improve lung transplant success.
It aims to understand and reduce complications like infection or rejection.
Participation involves sharing medical data and giving blood during regular clinic visits.
It won't change your current treatment but could help future patients.
You can stop participating at any time without affecting your care.

Who may be eligible?

To be part of this study, you need to be at least 18 years old and understand what you're agreeing to. You could be eligible if you're either waiting for a lung transplant, or if you've had a lung transplant within the last 30 days. This includes people having a second lung transplant or a transplant involving multiple organs, as long as they meet the other criteria.

However, there are reasons why you might not be able to join. If you, or someone legally able to make decisions for you, can't or won't agree to the study rules, you can't participate. Also, if you are pregnant or planning to become pregnant, you won't be able to join.

Finally, if the study doctor thinks that taking part might put you at extra risk, make it hard for you to follow the study plan, or affect the quality of the information they collect, then you might not be eligible.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Are you waiting for a lung transplant, or had one in the last 30 days?
Are you able to understand and agree to take part?
Are you currently not pregnant and not planning to become pregnant?

Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, it's designed to fit in with your usual medical care as much as possible. You won't have extra visits just for the study; instead, researchers will try to collect information and samples during your routine appointments and check-ups.

What this means for you is that the study team will regularly gather details about your health and treatment from your medical records. You'll also be asked to provide blood samples during some of your standard clinic visits. This might include collecting specific types of blood samples (like plasma and serum) and a DNA sample. If you're a recipient, a DNA sample from your donor might also be collected if possible. You may also be asked to fill out questionnaires about how you're feeling and your experiences.

Potential risks and benefits

Participating in this study won't directly improve your personal health, as there are no new treatments involved. However, the information gathered will be incredibly valuable for improving the care of future lung transplant patients. This could lead to a better understanding of complications, better ways to manage care, and ultimately, better outcomes for many people. The main risk involves giving blood samples, which might cause some minor discomfort or bruising. Your information will be kept confidential. Remember, you can decide to leave the study at any time, for any reason, without it affecting your medical care.

Locations (19)

University of California Los Angeles
Verified postcode
Los Angeles, United States· Recruiting
University of California at San Francisco
Verified postcode
San Francisco, United States· Recruiting
Stanford University Medical Center
Verified postcode
Stanford, United States· Recruiting
University of Miami
Verified postcode
Miami, United States· Recruiting
Johns Hopkins University
Verified postcode
Baltimore, United States· Recruiting
Brigham and Womens Hospital
Verified postcode
Boston, United States· Recruiting
University of Michigan
Verified postcode
Ann Arbor, United States· Recruiting
University of Minnesota
Verified postcode
Minneapolis, United States· Recruiting
New York University
Verified postcode
New York, United States· Recruiting
Columbia University
Verified postcode
New York, United States· Recruiting
Duke University Medical Center
Verified postcode
Durham, United States· Recruiting
University of Pennsylvania
Verified postcode
Philadelphia, United States· Recruiting

Common questions

What is the main goal of this study?

The study aims to understand how different medical practices and donor choices affect the success of lung transplants and how to prevent problems.

Will I get new treatment in this study?

No, this study is about observing and collecting information from your standard care, not about giving new treatments.

What do I need to do if I join?

You'll provide health information and blood samples during your regular check-ups, and possibly complete some questionnaires.

Is my personal information safe?

Yes, all your personal information collected for the study will be kept confidential.

Can I leave the study at any time?

Absolutely, you can choose to stop participating in the study at any point without it affecting your medical care.

How to find out more

Allyn Damman

allyn.damman@duke.edu 919-259-4414 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.