TLN-121 in Relapsed or Refractory Non-Hodgkin Lymphomas

To be considered for this study, you need to be at least 18 years old and have a specific type of non-Hodgkin lymphoma that has either come back or hasn't responded after previous treatments. The doctors will also check if your lymphoma can be measured, meaning they can see it and track its size. Your general health and how well you can go about your daily activities will also be reviewed to make sure you're well enough to take part. For example, your daily energy and activity levels will be assessed.

There are also some reasons why you might not be able to join the study. For instance, if your lymphoma has spread to your brain or spinal cord, you likely won't be able to participate. Also, if you've had certain other treatments recently, like a stem cell transplant or a special type of cell therapy (CAR T-cell therapy), you would need to wait a certain amount of time before joining. If you've had a big surgery or a serious medical condition that isn't under control, this might also mean you can't take part. These checks are to make sure the study is as safe as possible for everyone involved.

Taking part in this study would involve regular visits to the hospital for assessments. During these visits, doctors will check your overall health, ask about any symptoms you might have, and take blood samples to see how you're reacting to the medicine and how much of it is in your body. You'll receive the study medicine, TLN-121, possibly along with other treatments, as directed by the study doctors. Imaging scans, like CT scans, will be done regularly to see if your lymphoma is shrinking or changing. The total duration of your participation could vary, as you would continue treatment as long as it's helping you and you're not having side effects that are too difficult to manage, followed by a period where doctors continue to check in with you after treatment ends.