AuthorisedPhase II and Phase III (Integrated)Interventional

MECHANISMS OF NEURONAL RESILIENCE IN ALZHEIMER'S DISEASE AND ITS FOCAL VARIANTS: A MRI/PET STUDY

This research aims to understand how some brains are more resilient to Alzheimer's disease. Researchers will use advanced brain scans, called PET and MRI, to get a detailed picture of the brain. They will specifically look at how the build-up of a protein called tau, which is linked to Alzheimer's, affects different parts of the brain. The study will explore connections between tau levels and the brain's structure, how different parts of the brain communicate, and how these connections might change. The goal is to discover the natural ways the brain tries to protect itself, which could eventually help in developing new treatments for Alzheimer's disease.

At a glance

Status

Authorised

Phase

Phase II and Phase III (Integrated)

Sponsor

Institut National De La Sante Et De La Recherche Medicale

Enrolment target

Start

29 Jan 2025

Maladie d' Alzheimer Alzheimer's pathology

What is this study about?

This study is trying to understand why some people's brains handle Alzheimer's disease better than others. Think of it like a puzzle: Alzheimer's is known to cause a build-up of certain proteins, one of which is called 'tau'. When tau builds up abnormally, it can harm brain cells. However, scientists have noticed that not everyone with these protein changes shows the same level of memory and thinking problems. This study wants to find out why.

Researchers will use special types of brain scans, like PET and MRI. The PET scan uses a very small amount of a safe substance that sticks to the tau protein. This allows doctors to see exactly where and how much tau has built up in the brain. At the same time, MRI scans will provide detailed pictures of the brain's structure, like its size and the health of the connections between different brain parts. They will also look at how different brain areas work together when someone is resting.

By comparing these detailed brain pictures, the study hopes to find out how the amount and location of tau protein are linked to changes in the brain's structure and how it functions. They are particularly interested in how the brain might rewire itself or adapt to these changes. Understanding these natural coping mechanisms could be really important because it might lead to new ideas for treatments that help protect the brain from the effects of Alzheimer's disease.

Key takeaways

Researchers are studying how brains cope with Alzheimer's changes.
The study uses special PET and MRI brain scans to look at tau protein and brain structure.
It aims to understand why some brains are more 'resilient' to the disease.
Participation involves brain scans and a lumbar puncture (spinal tap).
No new medications are given; the study is for research purposes only.
This research could help develop future treatments for Alzheimer's disease.

Who may be eligible?

To take part in this study, you need to be an adult, 18 years old or older. There is no upper age limit, meaning older adults are welcome to participate as well.

Both men and women are invited to join the research. The study aims to include a diverse group of participants to get a broad understanding of brain resilience.

Further specific criteria would be discussed with you by the research team to ensure the study is right for you and you are right for the study.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Do you identify as male or female?
Are you comfortable having brain scans (PET and MRI)?
Are you willing to have a lumbar puncture (spinal tap)?

Answer every question to see your result.

What does participation involve?

If you decide to take part, the study will involve several visits for different types of brain scans. You will have a special scan called a PET scan, where a tiny amount of a tracking substance is injected to show tau protein in your brain. You will also have various types of MRI scans that take detailed pictures of your brain's structure and how different parts communicate. These scans are non-invasive and generally comfortable, though you will need to stay still inside a scanning machine for a period.

In addition to the scans, the researchers will collect samples of your cerebrospinal fluid (CSF) – the fluid that surrounds your brain and spinal cord. This is done through a procedure called a lumbar puncture, which involves a small needle inserted into your lower back. This sample helps them measure markers related to Alzheimer’s disease. You will not be given any new medication as part of this study; it focuses on understanding brain changes.

The total amount of time you spend in the study will depend on the schedule of these tests and possible follow-up observations. The research team will explain the exact number of visits, how long each visit will last, and the overall duration of your participation, so you know exactly what to expect.

Potential risks and benefits

Taking part in this study might not directly benefit your health immediately, but the information gained will be vital for understanding Alzheimer's disease and developing future treatments. Potential risks include discomfort from the lumbar puncture (like a headache) and a very small exposure to radiation from the PET scan, which is carefully controlled and considered safe. You will receive a detailed explanation of all potential risks before deciding to join. It is crucial to remember that your participation is completely voluntary, and you have the right to withdraw from the study at any time, for any reason, without affecting your usual medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

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Unverified
France

Common questions

What is 'tau' and why is it important in Alzheimer's?

Tau is a protein found in brain cells. In Alzheimer's, it can build up abnormally, forming 'tangles' that disrupt brain function. This study looks at how this build-up affects the brain.

What's the difference between a PET scan and an MRI scan?

A PET scan uses a special tracer to detect specific substances like tau protein, showing their activity. An MRI uses strong magnets and radio waves to create detailed images of the brain's structure and how it's connected.

Will I receive any new medication in this study?

No, this study is observational, meaning it focuses on understanding changes in the brain. You will not be given any new treatments or medications as part of your participation.

What is a lumbar puncture?

A lumbar puncture is a medical procedure where a small needle is used to collect a sample of cerebrospinal fluid (CSF) from your lower back. This fluid surrounds your brain and spinal cord and can provide valuable information about brain health.

Why is it important to understand 'brain resilience'?

Understanding brain resilience helps us learn why some people cope better with Alzheimer's disease changes. This knowledge could lead to new ways to protect the brain and develop treatments that promote healthier aging.