A Study of MK-5684 in People With Certain Solid Tumors (MK-5684-015/OMAHA-015)

This study is looking for adults aged 18 and over, of any sex. Generally, you might be able to take part if you have certain types of advanced or recurrent breast, ovarian, or endometrial cancer, and your cancer has either spread or come back after previous treatments.

For breast cancer, you would usually need to have hormone-sensitive breast cancer that has already advanced or spread, and has worsened despite at least one previous hormone-blocking treatment. For ovarian cancer, you would typically have a specific high-grade type and have received a certain number of chemotherapy cycles. For endometrial cancer, you would need to have an advanced or recurrent low-grade type, and either not had treatment yet or only one previous chemotherapy.

Everyone joining the study needs to be generally well, meaning any side effects from your past cancer treatments should have mostly cleared up. You would also need to have well-controlled HIV, if applicable, or well-managed Hepatitis B.

Taking part in this study would involve regular visits to the clinic for check-ups, assessments, and to receive your study medication (MK-5684 or a standard treatment). These assessments might include blood tests, scans, and physical exams to monitor your health and how the treatment is working. You will be closely followed by the study doctors and nurses. The duration of your participation would depend on how your treatment progresses and could continue as long as the treatment is beneficial for you and you tolerate it well. You'd also receive clear guidance on taking any other necessary medications.