Ongoing, recruitingTherapeutic use (Phase IV)Interventional

Steroids and/ or Non-steroidal Anti-inflammatory Drugs in the Postoperative Regime After Trabeculectomy. (SNAP)

This study, called SNAP, is investigating the best way to use eye drops after a type of glaucoma surgery called trabeculectomy. Glaucoma is a condition that can damage your eyesight, and sometimes surgery is needed to help reduce the pressure inside your eye. After this surgery, patients often use eye drops like steroids or anti-inflammatory drugs. The study wants to see how these different eye drops affect the pressure in the eye 12 months after surgery. It's also looking at how well patients see, any changes to their vision, and the health of their eyes over 24 months. The goal is to improve how doctors care for patients after glaucoma surgery.

At a glance

Status

Ongoing, recruiting

Phase

Therapeutic use (Phase IV)

Sponsor

Rigshospitalet

Enrolment target

Start

29 Nov 2024

Medically uncontrolled glaucoma that requires filtration surgery.

What is this study about?

This study, called SNAP, is looking into the best way to help people who have had a type of eye surgery for glaucoma. Glaucoma is an eye condition where the pressure inside your eye can get too high, which can damage your optic nerve and affect your vision. If medicines don't control the pressure, doctors might recommend an operation called trabeculectomy.

After this surgery, patients are usually given eye drops. These drops often contain either steroids or non-steroidal anti-inflammatory drugs (NSAIDs). The main aim of the SNAP study is to understand which of these eye drop treatments, or a combination, works best to keep the pressure inside your eye low 12 months after surgery. Keeping the eye pressure low is really important for protecting your vision in the long term.

The study will also check several other important things. This includes how well your vision is after 1 and 2 years, any changes to your field of vision (how much you can see around you), and the health of your optic nerve. Researchers will also look at the health of your eye's natural lens and how the surgical site is healing. By looking at all these things, the study hopes to find the best treatment plan to help patients recover well and maintain their eyesight after glaucoma surgery.

Key takeaways

The study looks at eye drops after glaucoma surgery.
It aims to find the best way to keep eye pressure low.
Participation involves using specific eye drops and regular check-ups.
It lasts for 2 years after surgery.
It's for adults needing trabeculectomy for uncontrolled glaucoma.
The goal is to improve care for future glaucoma patients.

Who may be eligible?

To join this study, you would need to be 18 years old or older. The study is open to both men and women.

The most important thing for joining is that you have a type of glaucoma that hasn't been controlled well enough with regular medicines and that your doctor has decided you need an operation called trabeculectomy. This study is for people who are about to have this specific surgery.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or over?
Have you been diagnosed with glaucoma that needs surgery?
Is your doctor recommending trabeculectomy surgery?
Are you able to attend follow-up appointments for two years?

Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, you will be given specific eye drops to use after your glaucoma surgery. These drops will be either a steroid, an anti-inflammatory drug, or a combination, and will be chosen by the study doctors. You would use them as instructed by your care team.

You would have several follow-up appointments over two years. At these visits, doctors would check your eye pressure, usually with a gentle touch test called applanation tonometry. They would also test your vision, check your field of vision, and might use special scanners to look at the health of your optic nerve and other parts of your eye like the lens. These check-ups are important for understanding how well the treatment is working. The total duration of your participation would be 24 months, with several visits during this time.

Potential risks and benefits

Taking part in this study might help doctors understand the best way to care for patients after glaucoma surgery, which could benefit future patients. For you, it might mean very close monitoring of your eye health, potentially identifying any issues sooner. However, like any medication, the eye drops used in the study have potential side effects, although these are generally mild. Your doctor will discuss these with you. You are free to withdraw from the study at any time without giving a reason, and this will not affect your usual medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

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Unverified
Denmark

Common questions

What is glaucoma?

Glaucoma is an eye condition where high pressure inside the eye can damage the nerve that connects your eye to your brain, potentially leading to vision loss.

What is trabeculectomy surgery?

It's an operation for glaucoma that creates a tiny new drainage channel in your eye to help lower the pressure when medicines aren't enough.

Why are eye drops needed after surgery?

Eye drops help with healing and to keep the eye pressure at the right level after the operation.

Will I know which eye drops I'm getting?

Your study doctor will explain all aspects of the treatment process to you before you agree to take part.

How long will I be in the study?

If you join, the study will follow your progress for 24 months (2 years) after your surgery.