A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast Cancer

To join this study, you generally need to be at least 18 years old and have advanced breast cancer that has either spread or can't be removed by surgery. You'll need to be well enough to take part, meaning you can handle daily activities without too much trouble, and your organs (like your liver and kidneys) should be working properly. Doctors will also need to be able to measure your cancer to see how the treatment is working.

There are also specific requirements depending on which group (cohort) of the study you might fit into. For example, some groups are only for specific types of breast cancer, like triple-negative or HER2-positive, or those with particular genetic changes. You'll need to have a recent tumour sample available for them to test, or be able to have one taken.

However, some things might prevent you from joining. For instance, if you've recently had certain types of immunotherapy or other cancer treatments, or if you're taking strong medications that suppress your immune system, you might not be able to participate. Your study doctor will review all your medical information carefully to see if this study is suitable for you.

If you decide to take part in this study, you will first be assigned to one of several treatment groups based on your type of breast cancer and past treatments. You'll then receive a specific combination of medicines. The study is divided into two main stages. In Stage 1, you'll receive your assigned treatment. For some patients, particularly those in one specific group with triple-negative breast cancer, if your cancer progresses or the treatment isn't working well, you might have the option to try a different treatment combination in Stage 2, if that part of the study is open.

Taking part will involve regular visits to the hospital for check-ups, blood tests, and scans to monitor your health and how the treatment is affecting your cancer. The specific frequency of these visits and tests will depend on the treatment you receive. You'll be given the study drugs, which could be pills or injections. The total duration of your participation will vary depending on how you respond to the treatment and the study's design for your specific group. There will also be follow-up appointments after your treatment period ends.