A Clinical Study to Test if an Investigational Treatment Called BNT314 When Used in Combination With Another Investigational Treatment BNT327 and Chemotherapy, is Beneficial and Safe for Patients With Advanced Colorectal Cancer

To be part of this study, you would generally need to have bowel cancer that has spread (advanced colorectal cancer) and has been confirmed under a microscope. Your cancer should not be of a specific type called `MSI-H` or `deficient mismatch repair`. You need to have cancer that can be measured, and you'll typically need to provide a recent tumour sample for tests. Your general health and ability to do daily activities should also be good, and you should be expected to live for at least 12 weeks.

Depending on which part of the study you might join, you may need to have already received at least two other types of treatment for your advanced cancer and found that your cancer progressed. Alternatively, some parts of the study are for people who haven't received any treatment for their advanced bowel cancer yet. You won't be able to join if your cancer is `MSI-H` or `deficient mismatch repair`, or if you've already had certain types of immune-boosting treatments for cancer.

It's important that your organs, like your liver and kidneys, are working well, and that you haven't recently had other treatments that might interfere with the study drugs. The research team will carefully check all these requirements with you.

If you join this study, it involves a few stages. First, there's a 'screening period' where tests are done to make sure you meet all the requirements. After that, you'll enter the 'treatment period', where you’ll receive the study drugs and regular check-ups. You'll continue treatment for as long as it's helping you, or for about 6 to 10 months on average, unless your cancer gets worse or you can't tolerate the treatment anymore.

Even after you stop taking the study drugs, there will be 'safety follow-up' to monitor your health and any side effects. There's also a 'long-term survival follow-up' period to monitor your overall health over a longer time. The study team will be regularly checking your safety, and for one part of the study, an independent group will also oversee patient safety.