AuthorisedPhase III and phase IV (Integrated)Interventional

Prestige 2- RimegePant in RElation to obeSiTy in miGainE

This study, called Prestige 2, is investigating a medicine called VYDURA 75 mg for people who get migraines. Researchers want to understand how effective this medication is at stopping migraine pain and other bothersome symptoms (like being sensitive to light or sound, or feeling sick) within two hours of taking it. They are particularly interested in how a person's body weight might affect how well the medicine works. The study will look at different doses (75 mg or two 75 mg tablets) and check for other things like how often people need to take other medicines for their migraine, and how long the relief lasts. It’s an important step to help doctors understand the best way to use this treatment for migraine sufferers.

At a glance

Status

Authorised

Phase

Phase III and phase IV (Integrated)

Sponsor

Konvent Der Barmherzigen Brueder

Enrolment target

Start

13 Mar 2026

Migraine

What is this study about?

This study is called Prestige 2, and it’s looking at a medicine called VYDURA 75 mg that is used to treat migraines. The main goal is to figure out how well this medicine works for people when they have a migraine attack. Specifically, the researchers want to see if taking VYDURA helps people become completely pain-free, or free from their most annoying migraine symptom other than the headache itself (like being very sensitive to light or sound, or feeling sick to their stomach) within two hours.

They are also very interested in how a person's body weight might influence how effective the medicine is. This is important because understanding this could help doctors decide on the best dose for different people in the future. The study is a "Phase III" and "Phase IV" study, which means it’s for medicines that are already quite advanced in their testing, or even already approved, but doctors want to learn more about them in real-world settings.

Beyond just getting rid of the pain, the researchers will also check other things like whether VYDURA helps with light and sound sensitivity, nausea, and how long the pain relief lasts. They’ll also be looking at whether people need to take other medicines for their migraine after taking VYDURA. By gathering all this information, they hope to get a much clearer picture of how VYDURA works for different people and how to best use it to help those who suffer from migraines.

Key takeaways

The study is about a migraine medicine called VYDURA 75 mg.
It aims to see if VYDURA stops migraine pain or other main symptoms within 2 hours.
Researchers are also looking at how body weight might affect the medicine's effectiveness.
Both men and women aged 18 and over can potentially take part.
Your participation could help improve migraine treatment for others.

Who may be eligible?

To be able to join this study, people need to be at least 18 years old. There is no upper age limit, so older adults can also take part.

Both men and women are welcome to participate in this research. The study needs a wide range of people to get a full understanding of how VYDURA works.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Do you get migraines?
Are you able to take medicine by mouth?
Are you willing to complete questionnaires about your migraine symptoms?
Are you comfortable with having blood tests?

Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, you would be given doses of the medicine VYDURA, either 75 mg or two 75 mg tablets, when you have a moderate to severe migraine. You would then be asked to fill in questionnaires. These questionnaires will ask about whether your pain has gone, if your most bothersome migraine symptom has improved after two hours, and if you’ve needed to take any other medication for your migraine within 24 hours. They will also ask about specific symptoms like sensitivity to light, sound, or nausea, and how long any relief from pain lasts. The study will also involve some blood tests to measure levels of the medication and other substances in your body, and checks on your body weight and composition. The specific number of visits and the total length of your participation would be explained fully by the study team.

Potential risks and benefits

Taking part in any study has potential benefits and risks. You might find that the VYDURA medicine helps your migraines, and your experience could help other people with migraines in the future. However, there’s always a chance the medicine might not work for you, or you could experience side effects, though the study team would explain any known risks. You are free to withdraw from the study at any time without giving a reason, and this would not affect your ongoing medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

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Unverified
Austria

Common questions

What kind of medicine is VYDURA?

VYDURA is a medicine taken by mouth that is being studied for treating migraine headaches.

What are they looking for in this study?

They want to see if VYDURA stops migraine pain or other really bothersome symptoms within two hours, and how body weight might affect this.

Do I have to take part if I'm interested?

No, showing interest doesn't mean you have to join. You can decide at any point not to participate.

What happens if I don't want to continue in the study?

You are free to stop your participation at any time, and it won't affect any medical care you receive.

Who can join this study?

Adults aged 18 and older, both men and women, who experience migraines may be eligible.