RecruitingOBSERVATIONAL

Prognostic Impact of the Location of Mitral Valve Prolapse on the Long-term Results of Mitral Plasty

This study investigates the long-term success of heart surgery called mitral valve repair (also known as 'mitral plasty'). This surgery fixes a common problem where the heart valve doesn't close properly, leading to a 'leaky' valve (mitral insufficiency). This problem affects many older adults in Europe. The study aims to understand if the specific location of the valve's 'floppy' part, called a prolapse, makes a difference to how well the repair works over time. For example, does it matter if the prolapse is on one side of the valve, or both? By studying patients who had this surgery between 1988 and 2011, researchers hope to improve how doctors decide the best way to fix these leaky valves.

At a glance

Status

Recruiting

Sponsor

Centre Hospitalier Universitaire, Amiens

Enrolment target

1,500

Start

04 Feb 2013

Estimated completion

04 Jul 2028

Mitral Valve Prolapse Mitral Plasty

What is this study about?

Imagine your heart has four main doors, called valves, that control the blood flow. One of these is the mitral valve, which acts like a one-way door between two chambers. Sometimes, this door can become a bit 'floppy' – a condition called mitral valve prolapse. When it's floppy, it doesn't close properly, and blood can leak backwards. Doctors call this 'mitral insufficiency', and it's a very common heart valve problem, especially as people get older.

When this leaking becomes a problem for a patient, surgery might be needed to fix it. The main type of surgery is called 'mitral plasty', which aims to repair the valve rather than replace it. The doctors performing the study want to understand if the exact location of the 'floppy' part of the valve makes a difference to how well the repair works in the long run. For example, is it easier to repair if only one part of the valve is floppy, or if both sides are affected?

By looking at a large group of patients who had this surgery a while ago, the study hopes to find out important information. This could help doctors make better decisions about treatment for patients with leaky mitral valves in the future, potentially leading to more successful and lasting repairs.

Key takeaways

This study evaluates long-term success of mitral valve repair surgery.
It focuses on how the exact location of the valve 'floppiness' impacts repair outcomes.
The research uses existing data from patients treated between 1988 and 2011.
Understanding these factors could lead to better future treatment decisions for patients.
It does not involve any direct patient participation or new procedures.
The study aims to improve understanding of a common heart valve condition.

Who may be eligible?

To be included in this study, patients must have had their mitral valve repair surgery between 1988 and 2011. They must also have a clear diagnosis of mitral valve prolapse (the 'floppy valve' condition) that was confirmed by a heart scan at the time. Finally, the researchers need to be able to access a complete medical history from when the heart scan was first performed.

There are also reasons why someone would not be included. For instance, if their leaky valve was caused by a heart attack or a specific type of heart muscle damage. Patients who also have other significant valve problems, like a very narrow aortic valve, or a very narrow mitral valve would not be eligible. Also, if someone has had previous heart surgery for any reason, they wouldn't be part of this particular study.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Did you have mitral valve repair surgery between 1988 and 2011?
Was your surgery to fix a 'floppy' mitral valve (mitral valve prolapse)?
Did you not have other major heart valve problems before your surgery?
Have you not had any other heart surgery in the past?
Was your leaky valve not caused by a heart attack?

Answer every question to see your result.

What does participation involve?

This study is looking back at medical records of patients who have already had mitral valve repair surgery. This means you wouldn't need to do anything new or have any extra appointments, tests, or take any medication. The researchers will simply be reviewing existing information from your past medical care. Therefore, there's no specific 'duration' of participation for you, as your involvement would be through your past medical data.

Potential risks and benefits

As this study involves reviewing existing medical records rather than direct patient involvement, there are no physical risks or demands on you. The main benefit is that by allowing your anonymised data to be included, you contribute to a better understanding of how different types of mitral valve repair work over many years. This could help improve future treatments for others facing similar heart problems. You always have the right to withdraw your consent for your data to be used in such a study, even if it's already part of the research.

Locations (1)

CHU Amiens Picardie
Verified postcode
Amiens, France· Recruiting

Common questions

What is mitral valve prolapse?

It's when your heart's mitral valve doesn't close properly, sometimes described as being 'floppy', which can cause blood to leak backwards.

What is mitral plasty?

Mitral plasty is a type of surgery that repairs the mitral valve, rather than replacing it, to stop blood from leaking.

Why are researchers interested in where the 'floppy' part is?

They want to see if the exact location of the prolapse affects how successful the valve repair surgery is in the long term.

Will I need to go to clinical appointments for this study?

No, this study looks at past medical records, so you won't need to attend any new appointments or tests.

Who can be in this study?

Adults who had mitral valve repair surgery between 1988 and 2011 for a specific type of valve problem, and whose medical history is available.

How to find out more

Catherine SZYMANSKI, Dr

szymanski.catherine@chu-amiens.fr +33322455885 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.