Phase IIa Study Evaluating AZD7798 in Crohn's Disease

This study is looking for adults aged between 18 and 80 years old who have been diagnosed with Crohn's disease. Your Crohn's disease needs to be active and either moderate or severe. This means it's causing significant symptoms even with current treatments.

We are particularly interested in people whose Crohn's affects their small bowel, large bowel, or both. You should also have tried other treatments (like steroids, azathioprine, or other advanced therapies) which haven't worked well enough, or you might rely on steroids to keep your symptoms under control.

There are also some reasons why you might not be able to join. For example, if you have other types of inflammatory bowel disease, very narrow or blocked parts of your bowel, or certain complications of Crohn's disease. You also can't be pregnant or breastfeeding. The study team will check all these details carefully to make sure the study is right and safe for you.

If you decide to join the study, you'll be regularly seen by the study team. This will involve visits to the clinic where you might have physical examinations, blood tests, and perhaps some scans or endoscopies (where a tiny camera looks inside your gut.) These tests help us monitor your health and see how the medicine is working.

You'll be given the study medicine (either AZD7798 or the placebo) as directed by the medical team. It's really important to take the medicine exactly as prescribed. You'll also be asked about your symptoms and how you're feeling throughout the study. The total time you'd be involved in the study would depend on the study design, and the research team will explain this fully during the consent process.