RecruitingNAINTERVENTIONAL

Imaging in Moyamoya Disease - Study to Investigate Different Imaging Technologies for a Better Understanding of Various Imaging Techniques to Evaluate Cerebral Hemodynamics, Disease-activity and Possibly the Etiology in Moyamoya Patients

This research is looking into different imaging methods, such as MRI and PET scans, to get a clearer picture of Moyamoya disease. The main goal is to figure out which imaging techniques work best for understanding how blood flows in the brain, tracking the disease as it develops, and possibly identifying what causes it. By doing this, the researchers hope to improve how doctors diagnose and care for patients with Moyamoya disease. They are especially interested in comparing new MRI techniques with existing scans and finding ways to recommend the best imaging practices for patients before and after surgery.

At a glance

Status

Recruiting

Phase

Sponsor

University Hospital Tuebingen

Enrolment target

Start

01 Jul 2024

Estimated completion

30 Nov 2027

Moyamoya Disease Moyamoya

What is this study about?

Moyamoya disease is a rare condition where the main blood vessels at the base of your brain become narrowed or blocked. To make up for this, the brain grows many tiny new blood vessels, which look like a 'puff of smoke' on scans – this is where the name 'Moyamoya' comes from, as it's a Japanese word for this appearance. Over time, for some people, this narrowing can get worse, possibly leading to strokes either from lack of blood flow or from tiny bleeds.

To prevent these serious problems, many patients might need surgery to help bring more blood to the brain. Before surgery, doctors need to know which parts of the brain aren't getting enough blood. Currently, there are different ways to check this, including special PET scans. However, these PET scans can be expensive, not widely available, involve a small amount of radiation, and require an injection and specific preparation.

This study is trying to improve patient care by finding better and easier ways to understand Moyamoya disease using imaging. Researchers are comparing advanced MRI techniques with the current standard PET scans. They are also looking at how changes in blood vessels seen on scans might link to blood samples and how the disease progresses over time. Ultimately, they hope to create clear guidelines for which scans are best to use for Moyamoya patients, both before and after any treatments, to ensure everyone gets the best possible care.

Key takeaways

Aims to improve how Moyamoya disease is diagnosed and monitored.
Compares advanced MRI techniques with current special PET scans.
Involves brain scans and blood sample collection.
Hopes to create better guidelines for imaging Moyamoya patients.
Participation could help improve care for future Moyamoya patients.

Who may be eligible?

This study is looking for adults aged 18 to 80 years old who might have Moyamoya disease. You would need to be able to understand what the study involves and agree to take part. Both men and women can participate.

However, there are certain situations that would prevent someone from joining. For example, if your blood vessel problems are due to other conditions like hardening of the arteries (atherosclerosis) or inflammation of the blood vessels (vasculitis), you would not be able to join. Also, if you have any reasons why you can't have an MRI or a PET scan, or if you are pregnant, you won't be able to take part.

Additionally, if you have severe kidney problems or if for any reason you aren't able to give your informed consent (meaning you can't fully understand and agree to participate), you would not be eligible for this study.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you between 18 and 80 years old?
Do you have suspected Moyamoya disease?
Are you able to have MRI and PET/CT scans?
Do you understand what the study involves and can you give your agreement to take part?
Are you currently pregnant?

Answer every question to see your result.

What does participation involve?

Taking part in this study would involve several visits for different types of scans. You would likely undergo MRI scans, which use strong magnets and radio waves to create detailed images of your brain. You might also have a special type of PET/CT scan, which uses a small amount of a radioactive substance (H2 15O) to show blood flow. One part of the MRI scan involves assessing how your brain's blood vessels react to changes in carbon dioxide levels, which might involve breath-holding exercises. The study also involves biosampling, meaning small samples of your blood would be collected. The total duration of your participation would depend on the study schedule, but the goal is to follow changes over time. Specific details about the number of visits, how long each visit will be, and the exact procedures will be thoroughly explained if you are considered for the study.

Potential risks and benefits

Potential benefits from participating include contributing to a better understanding of Moyamoya disease, which could lead to improved diagnosis and treatment for future patients. You might also receive advanced imaging that could offer insights into your own condition. Potential risks involve the standard considerations for MRI scans (such as claustrophobia or interactions with metal implants) and PET/CT scans (which involve a small amount of radiation exposure, similar to background radiation). Blood samples have minimal risk, primarily discomfort from the needle. You are free to withdraw from the study at any time, for any reason, without it affecting your medical care.

Locations (1)

University of Tuebingen, Neurosurgery
Verified postcode
Tübingen, Germany· Recruiting

Common questions

What is Moyamoya disease?

It's a rare condition where blood vessels at the base of the brain narrow, which can reduce blood flow and lead to strokes. The brain tries to compensate by growing tiny new vessels.

What kind of scans will I have?

You'll have different types of MRI scans and potentially a special PET/CT scan to look at blood flow in your brain.

Will I need to give blood samples?

Yes, the study involves taking blood samples to look for factors related to the disease.

Is there any radiation involved?

The PET/CT scan uses a very small amount of radiation, which will be carefully explained to you.

How long does the study last?

The study aims to track changes over time, so you would likely have appointments spaced out, but the exact duration will be discussed with you.

How to find out more

Constantin Roder, Prof. Dr., MD

constantin.roder@med.uni-tuebingen.de 0049-7071290 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.