AuthorisedTherapeutic use (Phase IV)Interventional

Long-term muscle synthetic effects of intradialytic parenteral nutrition in chronic hemodialysis patients

This research is investigating how a specific nutrient mixture, given directly into the bloodstream during a dialysis session (called Intradialytic Parenteral Nutrition or IDPN), affects muscle health. It's for adults who rely on regular dialysis for kidney failure. The main goal is to find out if this extra nutrition helps muscles grow and repair themselves better compared to not receiving it. Doctors will also check how amino acids (building blocks of protein) are used by the body and if there are any effects on blood pressure and heart function during dialysis when IDPN is given. This helps us understand if IDPN could be a helpful long-term treatment for muscle problems often seen in people on dialysis.

At a glance

Status

Authorised

Phase

Therapeutic use (Phase IV)

Sponsor

Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC)

Enrolment target

Start

27 Oct 2025

muscle protein turnover hemodialysis

What is this study about?

This study, which is in the final stages of research (Phase IV), is looking into a topic that is very important for people with chronic kidney disease who are receiving dialysis. Many people on dialysis can experience muscle weakness and loss over time, which can affect their overall health and quality of life. This research aims to understand if a special type of nutritional support, given during dialysis, can help improve muscle health.

The specific treatment being studied is called Intradialytic Parenteral Nutrition (IDPN). This involves giving nutrients, including protein building blocks (amino acids), directly into your bloodstream while you are having your regular dialysis session. The main question the researchers want to answer is whether this IDPN treatment can help your muscles build and repair themselves better over the long term, compared to when you don't receive this extra nutrition.

To find this out, the study will compare how quickly muscles make new proteins (a process called muscle protein turnover) in people receiving IDPN versus those who aren't. They will also look at how the body uses amino acids during dialysis and if IDPN has any impact on important body functions like blood pressure and how well the heart pumps during the dialysis session. The findings of this study could help doctors better support the muscle health of people on long-term dialysis.

Key takeaways

This study is for adults on long-term kidney dialysis.
It investigates if special nutrient feeds (IDPN) given during dialysis can help muscles.
Researchers will compare muscle building with and without IDPN.
It also checks how the body uses nutrients and impacts blood pressure during dialysis.
This is a short-term study focusing on effects over one week.
The results could help improve muscle health for dialysis patients.

Who may be eligible?

This study is open to adult men and women, aged 18 and older, who are currently receiving regular dialysis treatment for chronic kidney disease.

Quick self-check

Are you 18 years old or older?
Do you receive regular dialysis treatment for kidney disease?
Are you both male or female?
Are you willing to have extra monitoring during your dialysis sessions for one week?

This is a guide only — the research team will confirm whether you can take part.

What does participation involve?

If you decide to take part in this study, you would receive the special nutrient feed (IDPN) during your regular dialysis sessions for one week. During this time, researchers would carefully monitor how your body uses nutrients and how your muscles are working. They will take blood samples and possibly measure the balance of amino acids in your forearm during some dialysis sessions. They will also keep an eye on your blood pressure and heart function. This is a short-term study looking at effects over a one-week period.

Potential risks and benefits

Taking part in any study has potential benefits and risks. A potential benefit of this study is helping to understand if IDPN could improve muscle health for people on dialysis, which might lead to better treatments in the future. As IDPN is a form of medical nutrition, there could be risks associated with receiving nutrients directly into the bloodstream, such as changes in blood chemistry, or rarely, infection at the point of access. All procedures would be explained in detail, and your safety would be closely monitored by medical staff. Remember, you can choose to stop participating in the study at any time, for any reason, without it affecting your medical care.

Locations (1)

—
Netherlands

Common questions

What is IDPN?

IDPN stands for Intradialytic Parenteral Nutrition. It's a special mixture of nutrients, including proteins, fats, and sugars, given directly into your bloodstream during your regular dialysis treatment.

Why is this study important?

Many people on long-term dialysis can lose muscle strength. This study checks if giving extra nutrients during dialysis can help keep muscles healthy and strong.

Will I have to change my regular dialysis schedule?

No, you will receive the IDPN during your normal dialysis sessions, so your usual schedule won't change.

What will researchers be looking at?

They will be looking at how your muscles build new protein, how your body uses nutrients, and if there are any changes to your blood pressure or heart during dialysis with the IDPN.

How long will I be involved in the study?

The main part of the study involves receiving the IDPN treatment and being monitored for one week during your dialysis sessions.