Active not recruitingNAINTERVENTIONAL

Choroidal Response to Novel Spectacle Lens to Control Myopia Progression

This research is investigating a new design of spectacle lens aimed at slowing down the worsening of short-sightedness, also known as myopia, in children. Myopia makes distant objects appear blurry. Scientists have recently been looking at a part of the eye called the choroid and how its thickness changes throughout the day, and also its possible role in myopia getting worse. This study uses a new lens design that works by slightly changing how images appear at the edge of your vision. It's a three-year study mainly looking at how the new lenses affect eye length and vision in children aged 6 to 10. A part of this study will specifically focus on measuring choroid thickness.

At a glance

Status

Active not recruiting

Phase

Sponsor

SightGlass Vision, Inc.

Enrolment target

Start

18 Dec 2018

Estimated completion

31 Dec 2026

Myopia, Progressive

What is this study about?

This study is all about helping children who are short-sighted, also known as having myopia. Myopia means that things far away look blurry, and it often gets worse over time, especially in children. Scientists are trying to find new ways to slow down this worsening.

Recently, they've been very interested in a part of the eye called the choroid. Think of the choroid as a support layer at the back of your eye, full of blood vessels. It’s known that the thickness of this choroid can change naturally throughout the day. Researchers are now exploring if these changes, or the choroid itself, play a role in why short-sightedness gets worse.

So, what's new here? This study is testing a special new type of glasses lens. These lenses are designed to gently change how things appear at the edges of your vision. The idea is that this subtle change might help to slow down how quickly short-sightedness progresses. Ultimately, the goal is to find out if these new lenses are safe and effective in helping children with myopia.

Key takeaways

New eye measurements for children already in a myopia lens study.
Focuses on the 'choroid' layer of the eye to understand short-sightedness.
Aims to see how special new lenses might help slow down worsening myopia.
Measurements are non-invasive, like a photo of the eye.
Open to children aged 6 to 10 already participating in a related study.
Your child can withdraw from the study at any time.

Who may be eligible?

To join this particular part of the study, children would first need to be already taking part in another related study called CPRO-1802-001 (also known as Cypress_SG) at a specific research site called CORE. This ensures that the main requirements for the lens study have already been met.

Also, a child would need to understand what the study is about and agree to take part, which is called giving ‘assent’. Their parent or guardian would also need to read and sign a consent form, giving official permission for their child to participate.

Children generally can't join if they have a temporary health issue that might affect their eyes, like a common cold, active allergies causing eye irritation, or even if they're very tired. These types of temporary conditions could make the test results less accurate. The study is open to both boys and girls aged between 6 and 10 years old.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Is your child already in the CPRO-1802-001 (Cypress_SG) study at CORE?
Is your child aged between 6 and 10 years old?
Are you, as their parent/guardian, willing to sign a consent form?
Is your child healthy and not experiencing any temporary eye-affecting conditions right now (like bad allergies or a cold)?
Is your child able to understand and agree to take part?

Answer every question to see your result.

What does participation involve?

If a child is invited to take part in this specific sub-study, it means they are already participating in a larger study testing new spectacle lenses over three years. For this additional part, they would be asked to have special measurements of their choroid thickness taken at the CORE research site. These measurements are likely done using a non-invasive eye scan, similar to taking a picture of the back of the eye. This study is only concerned with these choroid measurements and does not involve any additional spectacles or medication. The overall duration is part of the three-year study, with specific appointments for these choroid measurements.

Potential risks and benefits

Potential benefits of taking part could include helping scientists better understand how short-sightedness progresses and how new lenses might help slow it down, potentially improving future treatments for children. There may not be direct personal benefits to the child in this particular part of the study, as it mainly involves measurements. Risks are expected to be very low, as choroid thickness measurements are usually non-invasive and painless, similar to having an eye scan. However, as with any study, participants have the right to withdraw at any time without giving a reason, and it will not affect their regular medical care.

Locations (1)

Centre for Ocular Research and Education
Verified postcode
Waterloo, Canada

Common questions

What is myopia?

Myopia is the medical term for short-sightedness, meaning you can see things clearly up close but distant objects appear blurry.

What is the choroid?

The choroid is a layer of tissue rich in blood vessels at the back of your eye, located between the retina (light-sensing layer) and the white outer layer (sclera). It helps to nourish the eye.

Will my child have to wear different glasses for this part of the study?

No, this specific part of the study doesn't involve wearing different glasses. It's focused on taking measurements of the eye.

How will choroid thickness be measured?

It will likely be measured using a special eye scan that is non-invasive and painless, similar to having a picture taken of the inside of the eye.

How long will this study last for my child?

This study for choroid measurements is part of a larger, three-year study your child may already be in. The measurement appointments will be scheduled within that timeframe.