RecruitingNAINTERVENTIONAL

Bridging Technique Validation for Nasolabial Folds JN-BRIDGE-1

This research is investigating a new and gentle way to treat smile lines, also known as nasolabial folds. It's called the Bridging Technique, and it uses tiny amounts of a special gel filler called AILEENE Vol. 2. The main goal is to see if this technique can safely and effectively reduce the appearance of these lines, making faces look more refreshed and natural, without using too much product. Researchers also want to know if people are happy with the results. This study is for adults aged 30 to 65 and involves a few visits to track progress and take pictures.

At a glance

Status

Recruiting

Phase

Sponsor

Dr. Joseph M Novoa Libermann

Enrolment target

Start

22 Nov 2025

Estimated completion

01 Nov 2026

Nasolabial Fold Correction Facial Aging Skin Rejuvenation Wrinkles Such as Nasolabial Folds

What is this study about?

You know those lines that sometimes appear from the sides of your nose down to the corners of your mouth? They're often called smile lines or nasolabial folds, and they're a common part of getting older as skin changes. Many people would like to soften them without looking like they've had a lot of work done. This study is exploring a new method, called the 'Bridging Technique,' which aims to do just that in a very subtle way.

Traditionally, some treatments might use more filler or different methods, but this new technique places very tiny amounts of a gel-like substance (called hyaluronic acid filler, specifically AILEENE Vol. 2) in fine lines under the skin. Think of it like building tiny, invisible bridges that gently support the skin and lift the folds, helping them look smoother without drastically changing your face. The doctors want to see if this method works well, if it's safe, and if people are pleased with how natural they look afterward.

This study is important because it wants to prove, with solid evidence, that this approach is effective and safe. If successful, it could offer a gentler, more natural-looking option for treating smile lines, which could be good news for many people. It also aims to give doctors clear information to help them use this technique safely and effectively in the future.

Key takeaways

This study tests a new, gentle filler technique for smile lines.
Aims for natural-looking results with less product.
Involves adults aged 30-65 with visible smile lines.
Participation includes free treatment, follow-up visits, and photos.
The study lasts for six months to check safety and effectiveness.
Your satisfaction and experience are important for the research.

Who may be eligible?

To join this study, you need to be an adult between 30 and 65 years old. You should have noticeable smile lines on both sides of your face that the study doctor grades as moderate or more. You also need to be generally healthy and willing to follow the study plan, including having some photos taken.

There are some reasons why you wouldn't be able to join. For example, if your smile lines are very mild, or if you've had other facial cosmetic treatments (like fillers, Botox, or certain skin procedures) in the last six to twelve months. You also can't participate if you have a known allergy to the filler ingredients, have an active skin infection in the treatment area, or are pregnant or breastfeeding.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you between 30 and 65 years old?
Do you have noticeable smile lines on both sides of your face?
Are you generally healthy, without certain long-term illnesses or skin problems?
Have you avoided other facial cosmetic treatments in the smile line area for the past 6-12 months?
Are you willing to attend regular follow-up appointments for six months?

Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, you'll receive a special face filler (AILEENE Vol. 2) injected into your smile lines using the new Bridging Technique. This will be done at no cost to you. You might receive up to one milliliter of filler in total for both sides of your face. If needed, a small top-up might be offered a few weeks later, using any remaining allowance from that one milliliter.

You'll have a few follow-up appointments: a quick virtual check-in after two weeks, and then in-person visits at week 4, month 3, and month 6. During these visits, photos of your face will be taken to see how the treatment is working. You'll also be asked to fill out short questionnaires about your satisfaction and experience. The study will last for six months in total.

Potential risks and benefits

Participating in this study means you could potentially benefit from having your smile lines softened in a natural-looking way, using a new and possibly more gentle technique, all at no cost. However, like any medical procedure, there are potential risks, such as temporary bruising, swelling, or redness at the injection site. Serious complications are rare but can occur with any filler injection. You will be fully informed of all possible risks before you decide to take part. Remember, joining is completely voluntary, and you have the right to withdraw from the study at any time without giving a reason.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

JNL Aesthetics Limited
Verified postcode
Warrington, United Kingdom· Recruiting

Common questions

What are 'nasolabial folds'?

These are the lines that run from the sides of your nose down to the corners of your mouth, often called smile lines.

What is the 'Bridging Technique'?

It's a new way of injecting tiny amounts of a special gel filler to gently support and soften smile lines, aiming for very natural results.

Will I have to pay for the treatment?

No, if you are accepted into the study, the filler treatment will be provided at no cost to you.

How long does the study last?

The study involves a few visits over a total period of six months.

What if I change my mind after joining?

You are free to leave the study at any time, for any reason, without telling anyone why.

How to find out more

Prof. Joseph M Novoa Libermann, MBBS

drjoe@jnlaesthetics.com +44 7722260964 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.