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NeoSCB App for Screening Jaundice in Newborns

Jaundice is common in newborns, making their skin and eyes look yellow. Doctors usually spot it by looking at the baby, but this isn't always accurate and can lead to unnecessary hospital visits for blood tests. This study is testing a new 'neoSCB' smartphone app designed to make this easier and more accurate. The app takes photos of the white part of a baby's eye (called the sclera) and then analyses how yellow it is to see if the baby might have jaundice. This new research will involve 405 newborn babies to check how well the app works compared to existing methods. The aim is to create an easy-to-use, low-cost tool that helps doctors quickly identify babies who need medical attention for jaundice, preventing potential serious problems.

At a glance

Status
Recruiting
Sponsor
University College, London
Enrolment target
405
Start
23 Sep 2025
Estimated completion
31 Mar 2027

What is this study about?

Jaundice is a common condition in newborn babies, where their skin and the whites of their eyes can look a bit yellow. This happens because of a substance called bilirubin that builds up in their blood. Most of the time, jaundice is harmless and goes away on its own. However, in some cases, if bilirubin levels get too high and are not treated, it can lead to serious health problems, though this is rare.

Currently, doctors often check for jaundice by looking at the baby. If they think the baby might have significant jaundice, they usually send them for a blood test at the hospital to measure the bilirubin level accurately. The problem is that judging jaundice by eye isn't always very precise. This can sometimes lead to babies being sent for blood tests they don't really need, causing stress for parents and extra work for hospitals.

This study is looking at a new smartphone app called 'neoSCB' that aims to make checking for jaundice much more accurate and easier. The app works by taking a picture of the white part of a baby's eye, called the sclera. It then uses a special programme to figure out how yellow the eye is. This study will involve 405 newborn babies and will test an improved version of the app to see how well it works. Researchers will also compare the app's accuracy to other devices currently used, to check if it's as good but at a much lower cost. They also plan to make the app even easier to use and add new features based on feedback from parents and healthcare staff. The ultimate goal is to provide a quick, simple, and affordable way to identify babies who truly need further checks or treatment for jaundice, helping to keep them safe and healthy.

Key takeaways

  • New smartphone app aims to improve jaundice screening.
  • Uses photos of baby's eye to detect yellowness.
  • Could provide a quicker, cheaper, and more accurate way to screen.
  • Study involves babies aged 0 to 28 days.
  • Participation is simple, non-invasive, and short-term.
  • Helps improve future care for newborns.

Who may be eligible?

To be part of this study, babies need to be born after 36 weeks of pregnancy and be between 0 and 28 days old. This means babies born full-term or just a little early can join.

However, babies cannot take part if they are very unwell and need urgent medical care. Also, if a baby has recently received light therapy (phototherapy) for jaundice, they won't be able to join this particular study.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

  1. Is your baby between 0 and 28 days old?
  2. Was your baby born after 36 weeks of pregnancy (full term or slightly early)?
  3. Is your baby generally well and not needing urgent medical care?
  4. Has your baby NOT recently had light therapy (phototherapy) for jaundice?
Answer every question to see your result.

What does participation involve?

If you decide for your baby to take part, the study team will use the 'neoSCB' app to take pictures of your baby's eye. They will also use two other devices, which are already available on the market, to measure your baby's bilirubin levels. These measurements are quick and non-invasive, meaning no needles are involved. There are no medications involved in this study. The study focuses on a single assessment at one time point, so there are no long-term follow-up visits specifically for the study. The total duration of your baby's involvement would be very short, just for the time it takes to perform these simple checks.

Potential risks and benefits

Taking part in this study could help improve how doctors screen for jaundice in babies, potentially leading to earlier and more accurate detection for many in the future. The simple checks involved are safe and painless, with no known risks to your baby beyond what is involved in routine care. You are free to withdraw your baby from the study at any time, for any reason, without it affecting your baby's medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.
  • UCL Hospitals
    Verified postcode
    London, United Kingdom· Recruiting

Common questions

What is jaundice in newborn babies?

Jaundice is a common condition in newborns where their skin and eyes look yellow. It happens when a substance called bilirubin builds up in their blood.

How does the 'neoSCB' app work?

The app takes a picture of the white part of your baby's eye and analyses how yellow it is to check for signs of jaundice.

Is the app safe for my baby?

Yes, taking pictures of your baby's eye with a smartphone app is completely safe and painless.

Will my baby need a blood test if they take part?

No, the study uses non-invasive methods (pictures and other devices) to check bilirubin levels. Blood tests would only be done if your baby's doctor decided it was necessary for their care, separate from the study.

What happens if the app shows my baby might have jaundice?

The app is a screening tool. If it suggests your baby has significant jaundice, their doctor will be informed and will decide if further checks or treatment are needed, just as they would with current methods.

How to find out more

Terence Leung, PhD

Always speak to your GP or specialist before deciding to take part in a study.

Interested in taking part?

Register your interest

Share your details and the research team for "NeoSCB App for Screening Jaundice in Newborns…" will contact you if you may be eligible. Always speak to your GP before agreeing to take part.

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