RecruitingNAINTERVENTIONAL

Beyond TME Origins

This study, called 'Beyond TME Origins', is for people who have advanced bowel cancer that has returned in the pelvic area. We're developing a new system using detailed MRI scans to help doctors better understand how the cancer is positioned. This helps them plan the best possible surgery and other treatments. We will also look back at information from when your cancer was first diagnosed to try and identify things that might increase the chances of it coming back. Patients taking part will have their treatment recorded and will be followed up for three years to see how they are doing. Our main goal is to improve treatment planning and care for people with recurrent bowel cancer.

At a glance

Status

Recruiting

Phase

Sponsor

Imperial College London

Enrolment target

383

Start

25 Sep 2014

Estimated completion

01 Dec 2031

Neoplasms Adenocarcinoma Carcinoma

What is this study about?

This study is called 'Beyond TME Origins'. It's all about improving how we understand and treat bowel cancer that has come back in the pelvis. When bowel cancer returns, especially in the pelvic area, it can be very complex. Doctors need the clearest possible picture to plan the best course of action, often involving a major operation called pelvic exenterative surgery. This study is working on a new way to describe and classify the returning cancer using special imaging like MRI scans.

The researchers will be using these new classifications to help doctors make more informed decisions about treatment. They will also look at your original scans and tissue samples from when your cancer was first treated. By doing this, they hope to learn more about what might make bowel cancer more likely to return. This knowledge could help doctors identify patients at higher risk in the future and potentially help prevent recurrence or catch it earlier.

Essentially, the study aims to give doctors better tools to assess the cancer's spread in the pelvis. This allows for more precise treatment planning, which could lead to better outcomes for patients. Throughout the study, your treatment will be carefully recorded, and your health will be monitored for three years to see the long-term effects of this new approach.

Key takeaways

Aims to improve treatment planning for recurrent bowel cancer in the pelvis.
Uses detailed MRI scans for a new way to classify cancer.
Investigates reasons why bowel cancer might return.
Participants' health will be monitored for three years.
No new medications are given as part of this study.
Could help future patients by improving understanding and treatment.

Who may be eligible?

To be considered for this study, you need to be at least 16 years old. You must have been diagnosed with bowel cancer (adenocarcinoma) that has now returned in your pelvic area, and this diagnosis needs to be confirmed.

You also need to have had surgery in the past for your original bowel cancer. Before joining, you must be able to have a detailed MRI scan, which helps doctors understand your cancer. Finally, you'll need to give your written permission to take part.

There are a few reasons why you might not be able to join. For example, if your cancer has spread beyond your pelvis to other parts of your body in a way that means it can't be removed by surgery. Also, if important medical records, like your initial scans or details of your previous treatment, are not available, you wouldn't be able to participate.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 16 years old or older?
Have you been diagnosed with bowel cancer that has come back in your pelvis?
Did you have surgery for your original bowel cancer?
Can you have a detailed MRI scan before treatment decisions?
Are your original medical records and scans available?

Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, the main things involved are a detailed MRI scan before any treatment decisions are made for your recurrent cancer. This scan is crucial for the new classification system being tested. Information from your original cancer diagnosis, including previous scans and tissue samples, will also be reviewed by the study team.

The treatments you receive for your recurrent cancer will be recorded carefully by the study team. You won't be given any new or experimental medications as part of this study; it's focused on how we assess and plan treatment for your existing condition. You will then be followed up for a period of three years, which means the study team will keep track of your health and how you are doing during this time.

Potential risks and benefits

Potential benefits from taking part in this study include contributing to a better understanding of recurrent bowel cancer and helping to develop improved ways for doctors to plan treatment for patients in the future. While there are no direct new treatments given in this study, the aim is that more precise staging will inform better surgical and treatment decisions for you. Potential risks are generally low as this study primarily uses existing medical information and standard diagnostic scans. The MRI scan is a routine procedure, though some people may find it uncomfortable due to the enclosed space or noise. You always have the right to withdraw from the study at any time, without giving a reason, and this will not affect your usual medical care.

Locations (4)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

Oslo University Hospital
Verified postcode
Oslo, Norway· Recruiting
St Mark's Hospital
Verified postcode
Harrow, United Kingdom· Recruiting
Churchill Hospital
Verified postcode
Oxford, United Kingdom· Recruiting
Royal Marsden Hospital NHS Foundation Trust
Verified postcode
Sutton, United Kingdom· Recruiting

Common questions

What kind of cancer is this study about?

It's about bowel cancer (specifically adenocarcinoma) that has come back in the pelvic area after initial treatment.

Will I get a new drug if I join this study?

No, this study isn't testing new drugs. It's looking at a new way to use scans to plan treatment and understand why cancer returns.

How long will I be involved in the study?

You'll be followed up for three years after your treatment for the recurrent cancer.

Do I have to have surgery to be in the study?

The study focuses on improving planning for surgery, but does not state surgery is an absolute requirement for participation. Your overall treatment will be recorded.

What is the main goal of this research?

The main goal is to improve how doctors assess and plan treatment for recurrent bowel cancer in the pelvis, hopefully leading to better outcomes for patients.

How to find out more

Caroline Martin

c.martin1@imperial.ac.uk +44 (0) 7749 655 817 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.