A Study of Amivantamab Subcutaneous (SC) Administration for the Treatment of Advanced Solid Malignancies

To be considered for this study, you must have a solid cancer (like certain lung, head and neck, colon, or breast cancers) that has spread or can't be removed with surgery. Your doctors must also believe that this type of treatment, which targets specific cancer growth pathways, could be helpful for you. You would typically have tried standard treatments already, or those options might not be suitable for you, or you may have chosen not to have them.

You would need to be generally well enough to take part, meaning you can do light daily activities, and if you are a woman who could become pregnant, you would need to confirm you are not pregnant and use effective contraception during and for a period after the study. Men with female partners who could become pregnant would also need to use contraception.

There are also some reasons why you might not be able to join, such as having other health conditions that are not well-controlled, like high blood pressure or diabetes, or if you have an active infection.

If you take part in this study, you will receive the study medication, amivantamab, as an injection under your skin. The specific dose and how often you receive it will depend on the study's plan for finding the best approach. You will have regular visits to the clinic for assessments, which will include checks on your overall health, blood tests (to monitor how the drug is working in your body), and safety evaluations to look for any side effects. The exact number of visits and the total duration of your participation would be explained in full by the study team, but typically, early phase studies involve close monitoring over several months, followed by longer-term follow-up.