EVALUATION OF OPIOID CONSUMPTION USING OBJECTIVE NOCICEPTIVE MONITORING IN PATIENTS INDICATED FOR DEEP SEDATION IN THE INTENSIVE CARE UNIT
This research is investigating how different types of sedation, like midazolam, isoflurane, and propofol, affect patients who are critically ill in intensive care with brain conditions. The main goal is to understand how these sedatives impact the amount of pain relief medication (opioids) patients need. The study will carefully monitor various aspects of the patient's health, such as their breathing, heart function, brain activity, and whether they develop infections. Researchers are also interested in how quickly patients wake up, if they experience confusion, how long they stay in intensive care and the hospital overall, and their survival rates. This will help doctors find the safest and most effective ways to sedate patients.
At a glance
What is this study about?
This study is a medical research project for critically ill patients in the Intensive Care Unit (ICU), specifically those with neurological conditions (affecting the brain or nervous system). When patients are very sick in the ICU, they often need to be deeply sedated, which means they are given medicines to make them deeply asleep and comfortable. This study is comparing different medicines used for sedation to see how they impact the amount of pain medication (called opioids) patients need.
The researchers will be looking at several important things. They will closely monitor patients' breathing, blood pressure, heart rate, and brain activity. They will also keep an eye on whether patients develop any infections. By carefully observing these different aspects, doctors hope to learn which sedation methods are most effective at keeping patients calm and pain-free, while also reducing the need for strong pain medications.
Beyond simply monitoring sedation, the study will also track how long it takes for patients to wake up once sedatives are stopped and if they experience confusion (delirium) during this time. They will also look at how long patients stay in the ICU and in the hospital overall, as well as their recovery and survival rates. The bigger picture is to find better ways to care for very sick patients, making their time in the ICU as safe and comfortable as possible, and helping them recover more effectively.
Key takeaways
- A study for critically ill adult patients in intensive care with brain conditions.
- Compares different sedation medicines (midazolam, isoflurane, propofol) on pain relief needs.
- Monitors breathing, heart, brain, and infection status.
- Looks at how quickly patients wake up and their hospital stay duration.
- Aims to improve comfort and safety for ICU patients.
- Participation involves no extra procedures, only careful monitoring of usual care.
Who may be eligible?
This study is open to adults aged 18 and older. Both men and women can take part.
To be considered for the study, you would need to be a patient in intensive care and require deep sedation for a neurological condition. This means you have a serious illness affecting your brain or nervous system that requires specialist care.
Specific medical details would be checked by the medical team to ensure the study is right for you and safe given your existing health conditions.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- Are you 18 years old or older?
- Are you currently an intensive care patient?
- Do you have a serious illness affecting your brain or nervous system?
- Do you (or your doctors) think you will need deep sedation?
What does participation involve?
If you are eligible and agree to take part (or your legal representative agrees if you're unable to), you wouldn't need to do anything extra beyond the care you'd already be receiving in the intensive care unit. The study involves your medical team closely monitoring your condition using standard ICU equipment and measurements, such as your breathing, heart rate, and brain activity. You would receive one of the study's sedation medications (midazolam, isoflurane, or propofol) as part of your treatment. The research team would collect information about your health, how much pain relief you need, and your recovery journey, including how long you stay in the ICU and hospital. There wouldn't be any additional hospital visits or follow-up appointments solely for the study; all monitoring happens during your stay.
Potential risks and benefits
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Common questions
What is 'deep sedation'?
Deep sedation means you are given strong medicines to make you deeply asleep and comfortable, often when you are on a breathing machine in hospital.
What are 'opioids'?
Opioids are strong pain relief medicines. Doctors want to understand how much is needed with different sedatives.
Will I get extra tests if I join?
No, you won't get any extra tests or procedures specifically for the study beyond what's part of your usual intensive care treatment.
What does 'neurocritically ill' mean?
It means you have a very serious medical condition affecting your brain or nervous system, requiring intensive hospital care.
Can I leave the study if I change my mind?
Yes, you (or your legal representative) can decide to leave the study at any time without it affecting your medical care.
How to find out more
Always speak to your GP or specialist before deciding to take part in a study.
Discussion
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