AuthorisedTherapeutic use (Phase IV)Interventional

A pharmacokinetic study of desmopressin - Minirin vs Sandoz

This research study is comparing two common versions of a medicine called desmopressin, which is used to help with bedwetting (nocturnal enuresis). The two versions are ‘Minirin’ and ‘Sandoz’. Both are types of tablets that dissolve under the tongue. The main goal is to see how much of the medicine gets into the body and how long it stays there for both Minirin and Sandoz. Researchers will also look at how quickly the medicine starts to work, its effect on urine, and if patients prefer one tablet over the other based on taste and texture. This study is open to anyone who experiences bedwetting.

At a glance

Status

Authorised

Phase

Therapeutic use (Phase IV)

Sponsor

Region Midtjylland

Enrolment target

Start

17 Jun 2025

Nocturnal enuresis

What is this study about?

This research is looking into a common problem called bedwetting, which is also known as nocturnal enuresis. Many people, including children and adults, experience bedwetting, and it can be a distressing issue. One of the main treatments for bedwetting is a medicine called desmopressin. This medicine helps your body produce less urine overnight, which can prevent accidents.

There are different forms of desmopressin available. This study specifically compares two types of tablets that you place under your tongue: one called 'Minirin' and another called 'Sandoz'. The main aim is to understand how your body handles each of these medications. Researchers want to see if both medicines are absorbed into your bloodstream in a similar way and at a similar speed.

On top of that, the study will also look at how effective each medicine is by checking things like how much urine you produce and how concentrated it is. They're also interested in what people think about taking each tablet – whether one tastes better or feels nicer to take than the other. This kind of research helps doctors understand which treatments work best and which might be preferred by patients, leading to better care for people with bedwetting.

Key takeaways

Compares two desmopressin brands for bedwetting.
Investigates how the body absorbs each medicine.
Checks for patient preference regarding taste and texture.
Open to anyone experiencing bedwetting, regardless of age or gender.
Aims to improve bedwetting treatment options.

Who may be eligible?

This study is open to anyone who experiences bedwetting, regardless of their age or sex. If you are experiencing bedwetting, you might be able to take part.

You do not need to meet any specific age criteria (such as being a child or an adult), nor does your sex affect whether you can join.

The researchers are looking for a wide range of participants to get a good understanding of how these medicines work across different people.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Do you experience bedwetting?
Are you of any age (child or adult)?
Are you male or female?
Are you willing to take specific medications for the study?
Are you willing to provide blood and urine samples?

Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, you will be given two different versions of desmopressin medicine – Minirin and Sandoz – at different times. These are small tablets that dissolve under your tongue. Researchers will take blood and urine samples from you at specific times after you take the medication. This helps them measure how much of the medicine is in your body and how it's affecting your urine. You might also be asked about your experience with each tablet, such as its taste and texture. The study will likely involve several visits to a clinic over a period of time to complete these assessments, but the overall duration and number of visits will be explained in detail before you agree to participate.

Potential risks and benefits

Taking part in this study could offer some benefits by helping to find the best way to treat bedwetting. You might gain a better understanding of your own condition. As with any medication, there are potential risks, such as side effects from desmopressin (though these are generally mild and well-known). There will also be some discomfort from blood sample collections. All procedures will be explained thoroughly, and your safety will be closely monitored. Remember, you can choose to leave the study at any time, for any reason, without it affecting your medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

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Unverified
Denmark

Common questions

What is bedwetting?

Bedwetting (or nocturnal enuresis) is when you accidentally wet the bed during sleep. It's a common problem that can affect both children and adults.

What is desmopressin?

Desmopressin is a medicine that helps reduce the amount of urine your body produces, especially overnight, to help prevent bedwetting.

What's the difference between Minirin and Sandoz?

Minirin and Sandoz are two different brands of the same medicine, desmopressin. This study is checking if they work similarly in your body and if people prefer one over the other.

Will I have to stay overnight?

The study description doesn't specifically say, but typically for this type of measurement, you would attend a clinic for several hours after taking the medicine, rather than staying overnight.

Will I know my results?

While individual results are usually kept private, the overall findings of the study will eventually be published and shared with the medical community.