Tailored antiplatelet secondary prevention in non-cardioembolic ischemic stroke: a phase IV gender-stratified randomized controlled trial (TAILOR trial)
This research, called the TAILOR trial, is for people in the UK who have had a specific kind of stroke that wasn't caused by a heart problem. The main aim is to see which of three common medicines (Aspirin, Ticlopidine, or Clopidogrel) is best at stopping another stroke, a heart attack, or death due to heart or blood vessel problems over one year. The study also wants to find out if these medicines work differently for men and women. In addition, it will look at how well people take their medicine, their recovery, and any side effects like bleeding. The goal is to improve how we prevent future health problems after a stroke.
At a glance
What is this study about?
Imagine you've had a type of stroke that wasn't caused by a heart problem. This trial is all about finding the best way to prevent you from having another stroke, a heart attack, or other serious heart-related issues in the future. Doctors often prescribe medicines to thin your blood and stop clots from forming after a stroke. This study specifically looks at three well-known medicines: Aspirin, Ticlopidine, and Clopidogrel.
The researchers want to compare these treatments carefully to see which one works best over a year. They'll be checking how many people have another stroke, a heart attack, or die from heart problems. They are also very interested in whether these medicines work differently for men and women, as sometimes treatments can have varying effects depending on a person's sex.
Beyond preventing serious events, the study will also look at other important things. For example, they'll see how easy it is for people to remember to take their medicine and how well their blood responds to the treatment. They'll also check on your overall recovery and well-being a year after the stroke, and monitor for any side effects, particularly bleeding, which can sometimes happen with blood-thinning medicines.
Key takeaways
- Compares three common anti-clotting medicines after a specific type of stroke.
- Aims to find the best treatment to prevent another stroke, heart attack, or cardiovascular death.
- Lasts for 12 months with follow-up appointments.
- Will assess if treatments work differently for men and women.
- Monitors for side effects, particularly bleeding.
- You can stop participating at any time.
Who may be eligible?
To be considered for this study, you need to be a man or a woman aged 18 or older. You must have recently had a specific type of stroke known as a 'non-cardioembolic ischemic stroke'. This means your stroke was caused by a blood clot blocking an artery, but it wasn't due to a clot that travelled from your heart.
The research team will have a full list of things they look for to make sure the study is right for you and that the results are clear. This includes checking your past medical history and current health.
It's important to discuss with your doctor if this study could be a good fit for you. They can help determine if you meet all the necessary requirements and if taking part is suitable for your individual health situation.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- Are you 18 years old or older?
- Have you recently had a stroke?
- Was your stroke caused by a blood clot (ischemic stroke)?
- Was your stroke NOT caused by a heart problem (non-cardioembolic)?
- Are you generally healthy enough to participate in a study?
What does participation involve?
If you decide to take part in this study, you will be given one of three common medicines: Aspirin, Ticlopidine, or Clopidogrel. You will need to take this medicine as prescribed throughout the study. The study will last for 12 months, and during this time, you'll have check-ups with the research team.
These check-ups will usually happen at 3 months and 12 months. During these visits, the research team will ask you questions about how you’re feeling and if you’ve had any health problems. They will also ask about how you’re taking your medicine to make sure you’re sticking to the plan. You may have some blood tests to see how your body is responding to the medicine and to check for certain genetic markers. The overall commitment is to take your assigned medication and attend these follow-up appointments over one year.
Potential risks and benefits
Locations (1)
- —UnverifiedItaly
Common questions
What type of stroke is this study for?
This study is for people who have had a specific type of stroke called a 'non-cardioembolic ischemic stroke.' This means the stroke was caused by a blood clot but didn't come from the heart.
What medicines are being studied?
The study will compare three common medicines: Aspirin, Ticlopidine, and Clopidogrel, which are all used to help prevent blood clots.
How long will I be in the study?
Your involvement in the study, including taking the medicine and having check-ups, will last for 12 months.
*Will this study help me directly?
*While the main goal is to improve future stroke prevention, you would receive a standard treatment known to help, and your health will be closely monitored by medical professionals.
What does a 'gender-stratified' study mean?
It means the researchers will specifically look to see if the medicines work differently for men compared to women, to understand any sex-specific effects.
How to find out more
Always speak to your GP or specialist before deciding to take part in a study.
Discussion
Community discussion
Powered by our forum at community.patient.info. Please be respectful — this is not medical advice.