Adjuvant Chemotherapy in Patients With Intermediate or High Risk Stage I or Stage IIA Non-squamous Non-Small Cell Lung Cancer: AIM-HIGH (Adjuvant Intervention in Molecular High Risk Patients)

To join this study, you would need to be 18 years old or older and have had surgery to completely remove a non-squamous non-small cell lung cancer that was either Stage I or IIA. Your general health should be good enough to potentially receive chemotherapy, and you would need to be willing to be put into one of the study groups by chance (randomised).

You would not be able to join if your cancer was a different type (like pure squamous, small cell, or neuroendocrine lung cancer), or if it was more advanced than Stage IIA. If you are pregnant or breastfeeding, or if you have certain other serious health conditions that would make chemotherapy unsafe, you also wouldn't be able to take part. Having certain other cancers recently or being on other experimental drugs could also stop you from joining.

If you decide to take part, your doctor will first check if you meet all the requirements for the study. If you do, and after discussing everything and giving your consent, you would then be randomly assigned to one of two groups. One group would receive additional chemotherapy after your surgery, and the other group would continue with regular check-ups (radiographic surveillance). The specific type and timing of chemotherapy would be discussed with you.

Both groups would have regular follow-up appointments and scans over a period of about five years to keep an eye on your health and check for any signs of the cancer returning. You would need to be willing to attend these appointments as scheduled. The study involves collecting information about your treatment and health outcomes during this time.