RecruitingPHASE3INTERVENTIONAL

JoLT-Ca Sublobar Resection (SR) Versus Stereotactic Ablative Radiotherapy (SAbR) for Lung Cancer

This study, called JoLT-Ca, is looking at two ways to treat early-stage lung cancer: Stereotactic Ablative Radiotherapy (SAbR), which is a very focused type of radiation, and a smaller surgery called sublobar resection. The main goal is to find out if SAbR helps people with this type of lung cancer live longer and better than receiving the smaller surgery. This research is especially for people who might be considered high-risk for more extensive surgery. By comparing these two treatments, doctors hope to find the best approach to help patients with early lung cancer.

At a glance

Status

Recruiting

Phase

PHASE3

Sponsor

University of Texas Southwestern Medical Center

Enrolment target

272

Start

01 Jul 2015

Estimated completion

01 Dec 2028

Non-Small Cell Lung Cancer

What is this study about?

This study is comparing two important types of treatment for a common type of lung cancer called non-small cell lung cancer, specifically in its early stages. These are Stereotactic Ablative Radiotherapy (SAbR) and a surgical procedure called sublobar resection. SAbR is a very precise way to deliver high doses of radiation to a tumour, aiming to destroy the cancer cells while protecting healthy tissue around it. A sublobar resection is a type of surgery where only a small part of the lung containing the cancer is removed, rather than a whole lobe.

The main purpose of this study is to see which of these two treatments works better for people with early-stage lung cancer who might find a bigger surgery too difficult or risky. Researchers want to know if SAbR can help these patients live longer and improve their overall health compared to the smaller surgery. This is important because previous studies have suggested that SAbR might be very effective, and this trial aims to confirm that with strong evidence.

By taking part, patients will help doctors understand the best way to treat this type of lung cancer. This could lead to better treatment options for many people in the future. The study is very carefully designed to give clear answers about the benefits and risks of each treatment.

Key takeaways

Compares two treatments for early lung cancer: precise radiation (SAbR) and small surgery.
Aims to find out which treatment helps patients live longer and healthier.
Specifically for early-stage non-small cell lung cancer that hasn't spread.
Participants will be closely monitored for at least two years after treatment.
Your general health and tumour size are key factors for joining.

Who may be eligible?

To join this study, you need to be at least 18 years old. Doctors will check your general health to make sure you're well enough for either treatment option. You must have been diagnosed with non-small cell lung cancer in its early stages, and the tumour should be no larger than 4 cm.

Importantly, your cancer must be located in a part of the lung where the smaller surgery (sublobar resection) can be safely performed, and it shouldn't be too close to your main airways. Doctors will also need to confirm that the cancer hasn't spread to your lymph nodes or other parts of your body. Finally, you'll need to have had some breathing tests recently to check your lung function.

The medical team will review all your scans and test results carefully to make sure you meet all these requirements. If you have any questions about whether you might be eligible, it's best to discuss them with your doctor.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years or older?
Do you have early-stage non-small cell lung cancer?
Is your lung cancer tumour 4 cm or smaller?
Has your doctor confirmed the cancer hasn't spread to other parts of your body?
Have you had recent breathing tests to check your lung function?

Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, you'll go through a screening process first to make sure you meet all the health requirements. Once confirmed, you'll be told which treatment group you've been assigned to: either the special radiation (SAbR) or the smaller lung surgery (sublobar resection). Even after you know your assignment, you still have the right to decide if you want to proceed with the study or not.

If you agree to participate, you will receive the assigned treatment. After the treatment, you will have regular check-ups and follow-up appointments with the medical team for at least two years. These appointments will involve tests and scans to monitor your health and how well the treatment is working. This helps the researchers collect important information about the long-term effects of each treatment.

Potential risks and benefits

Taking part in this study could offer you a potential benefit of receiving advanced treatment for your lung cancer, and you'll be closely monitored by a team of specialists. However, both surgery and radiation carry potential risks, such as side effects from the treatment itself, which your doctor will explain in detail. There's also the chance that the treatment may not work as effectively as hoped. It's really important to know that you have the right to withdraw from the study at any time, for any reason, without it affecting your medical care.

Locations (50)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

UCSD
Verified postcode
La Jolla, United States· Completed
University of Colorado/Memorial
Verified postcode
Aurora, United States· Completed
Penrose Cancer Center
Verified postcode
Colorado Springs, United States· Completed
Boca Raton Regional Hospital
Verified postcode
Boca Raton, United States· Completed
Curtis and Elizabeth Anderson Cancer
Verified postcode
Savannah, United States· Recruiting
University of Iowa
Verified postcode
Iowa City, United States· Terminated
University of Kansas Medical Center
Verified postcode
Kansas City, United States· Completed
University of Kentucky Health Care
Verified postcode
Lexington, United States· Completed
University of Louisville Physicians
Verified postcode
Louisville, United States· Active not recruiting
Ochsner Medical Center
Verified postcode
New Orleans, United States· Completed
Luminis Health Research Institute
Verified postcode
Annapolis, United States· Active not recruiting
University of Maryland Medical Center
Verified postcode
Baltimore, United States· Completed

Common questions

What is non-small cell lung cancer?

It's the most common type of lung cancer, and this study focuses on it when it's found in its early stages.

What does 'SAbR' mean?

SAbR stands for Stereotactic Ablative Radiotherapy. It's a very precise type of radiation treatment that targets the cancer with high doses.

What is 'sublobar resection'?

This is a type of surgery where only a small part of your lung, where the cancer is located, is removed.

Why is this study important?

It helps doctors understand which treatment, SAbR or sublobar resection, is better for people with early-stage lung cancer, especially those who might find bigger surgeries too risky.

Can I choose which treatment I get?

No, you'll be assigned to one of the treatment groups by chance, like flipping a coin. This helps make the study fair.

How to find out more

Sarah Neufeld, MBA

sarah.hardee@utsouthwestern.edu 214-645-8525 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.