A Study to Evaluate the Efficacy and Safety of Multiple Targeted Therapies as Treatments for Participants With Non-Small Cell Lung Cancer (NSCLC)

To join this study, you generally need to have a confirmed diagnosis of non-small cell lung cancer that is advanced or has spread, meaning it cannot be removed by surgery or treated with combined chemotherapy and radiation. You should also be well enough to carry out most of your daily activities, and your cancer needs to be measurable, so doctors can track how it responds to treatment. Your organs, such as your liver and kidneys, need to be working well, and you should have recovered from any previous cancer treatments.

There are also some reasons why you might not be able to join. For example, if you are pregnant or breastfeeding, or if you can't swallow pills. You also wouldn't be able to join if your cancer has spread to your brain and is causing symptoms that aren't controlled, or if you've had another cancer within the last five years (unless it was a very low-risk type). Certain heart conditions, active HIV, or other serious health problems that might make the study drug unsafe or make it hard to understand the study results would also prevent participation.

All participants must also be willing to use effective contraception if they could become pregnant or get someone pregnant during the study.

If you join this study, you would receive one of the study medications. These could be tablets you take by mouth, or infusions given directly into your bloodstream. You would have regular visits to the clinic for medical check-ups, blood tests, scans (like CT scans) to see how the treatment is working, and to discuss any side effects you might be experiencing. These visits would happen more frequently at the beginning of the study and then might become less often if the treatment is working well. After you finish taking the study medicine, you'll have follow-up visits or contact to monitor your health. The total duration of your participation, including treatment and follow-up, will depend on how your cancer responds to the treatment and your general health, but could last for quite some time.