A Global Study to Assess the Effects of Durvalumab With Oleclumab or Durvalumab With Monalizumab Following Concurrent Chemoradiation in Patients With Stage III Unresectable Non-Small Cell Lung Cancer

To join this study, you must be at least 18 years old and have a confirmed diagnosis of Stage III Non-Small Cell Lung Cancer that doctors have said cannot be removed by surgery. You must have already completed a combined treatment of chemotherapy and radiation, and your cancer should not have grown or spread since then. We would also need a tissue sample from your cancer before your chemotherapy and radiation treatment.

There are also some health requirements, such as having good general health and your major organs working properly. Your medical team will check details about your specific type of lung cancer, including certain genetic markers, to make sure this study is right for you. They will also need to ensure that any side effects from your previous chemotherapy or radiation treatment have mostly cleared up, especially lung inflammation (pneumonitis).

You wouldn't be able to join if you have cancer that's mixed with another type called small cell lung cancer, or if you've recently had another type of cancer that hasn't been completely cured. If your cancer grew worse during or immediately after your chemotherapy and radiation, or if you have certain lung conditions like severe scarring, you also wouldn't be able to participate.

If you decide to take part, you'll be assigned by chance to one of three treatment groups. This is a 'double-blind' study, meaning neither you nor your study doctor will know which treatment you are receiving – Durvalumab with Oleclumab, Durvalumab with Monalizumab, or Durvalumab with a placebo. You would come to the clinic for regular visits where you'd receive your study medications, which are given as infusions (into a vein).

During these visits, you'll have various tests and assessments, including blood tests, scans (like CT scans) to check your cancer, and physical examinations. These are to monitor your health, check for side effects, and see how the treatment is working. The study involves regular treatment for an extended period, and you'll have follow-up visits even after you stop taking the study medication to keep track of your health long-term. Your study team will explain the exact schedule of visits and procedures in detail, and you'll always have the right to ask questions.