Not yet recruitingNAINTERVENTIONAL

Incretin-based Therapies, Nutrition, and Physical Activity

This study, called "Incretin-based Therapies, Nutrition, and Physical Activity", aims to find out if combining a special weight-loss medicine with a six-month programme of healthy eating and exercise helps adults with obesity keep their muscle mass and improve their movement better than just taking the medicine alone. \n\nThe researchers also want to see if it's practical to work with local community health services to deliver this kind of programme. About 120 adults between 18 and 70 will take part. They will all start a medicine that helps with weight loss. Half will also get the eating and exercise plan, while the other half will just have the medicine. Participants will be followed for a year to see the results.

At a glance

Status

Not yet recruiting

Phase

Sponsor

Laval University

Enrolment target

120

Start

01 Mar 2026

Estimated completion

01 Mar 2028

Obesity & Overweight Cardiometabolic Conditions

What is this study about?

This study is designed to help us better understand how to support adults living with obesity. We know that newer medicines can help with weight loss, but sometimes when people lose weight, they can also lose valuable muscle, which is important for strength and everyday activities. This research wants to explore if adding a structured programme of exercise and healthy eating alongside these new weight-loss medications can help people keep their muscles strong and improve their physical fitness.

Over one year, we will compare two groups. Everyone in the study will be prescribed a type of weight-loss medication. One group will just take this medication. The other group will take the same medication but will also receive a six-month lifestyle programme. This programme will include supervised exercise sessions focused on building strength, along with advice on healthy eating. After these six months, this group will continue to get support for another six months.

We're also looking at how well a new way of working can help. The study will assess if it's practical and effective for hospitals and local community centers (like exercise facilities) to work together to offer these kinds of support programmes to patients. Your participation could help us find better ways to help people manage their weight and stay healthy.

Key takeaways

A one-year study for adults (18-70) with obesity.
Compares weight-loss medicine alone versus medicine plus exercise and healthy eating.
Aims to protect muscle and improve physical fitness during weight loss.
Involves regular check-ups over 12 months.
Seeks to improve collaborative care between hospitals and local services.
You will be randomly assigned to one of two groups.

Who may be eligible?

To join this study, you need to be an adult between 18 and 70 years old. You should have obesity, which means your Body Mass Index (BMI) is 30 or higher. If your BMI is 27 or higher and you also have another health condition like type 2 diabetes or high blood pressure, you might also be able to take part. A key requirement is that your doctor has recently prescribed you a new weight-loss medicine, but you haven't started taking it yet.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you between 18 and 70 years old?
Has your doctor prescribed you a new weight-loss medicine (but you haven't started it yet)?
Is your BMI 30 or higher, or 27 or higher with another health condition like diabetes or high blood pressure?
Are you able to do physical activity safely?
Are you not pregnant, breastfeeding, or planning to become pregnant during the next year?
Do you not have a pacemaker or similar medical device implanted?

Answer every question to see your result.

What does participation involve?

If you join this study, you'll be part of it for a total of one year. Everyone in the study will start a specific weight-loss medication prescribed by their doctor as part of your usual care. You'll be randomly put into one of two groups: either the group that only takes the medication, or the group that takes the medication and also gets a special six-month programme. This programme includes supervised exercise sessions and regular nutrition advice. After six months, this group will continue to receive support for another six months.

Throughout the year, you will have check-ups and assessments at the start of the study, and then at 3, 6, and 12 months. These assessments will help us understand how your body is changing. If you are in the medication-only group, at the end of the study you will still receive a personalised consultation with a dietitian and an exercise specialist.

Potential risks and benefits

Taking part in this study may offer personal benefits, such as receiving expert advice on exercise and nutrition, which could help improve your health and well-being. The study aims to find better ways to help people manage their weight and keep their muscle strength, so your participation could contribute to wider knowledge. As with any medical study, there may be some risks, including potential side effects from the medication or the physical activity. These will be fully explained to you before you decide to take part. Remember, you can choose to leave the study at any time, for any reason, without it affecting your medical care.

Locations (1)

Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval
Verified postcode
Québec, Canada

Common questions

What kind of medicine will I take?

You will take a new type of weight-loss medicine (called an 'incretin-based therapy') that your doctor has prescribed, but which you haven't started yet.

What does a 'structured lifestyle programme' involve?

It means you'll have supervised exercise sessions focused on strengthening your muscles, alongside regular meetings with an expert for advice on healthy eating.

How long will the study last?

The study will last for one year in total.

Who will deliver the exercise and nutrition advice?

The exercise sessions will be delivered in collaboration with an exercise facility, and you'll get nutrition counselling from experts.

Can I leave the study if I change my mind?

Yes, you are free to leave the study at any time without giving a reason, and it will not affect your medical care.

How to find out more

Elisa Marin-Couture, Kin, PhD

elisa.marin-couture.1@ulaval.ca 1-418-656-8711 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.