A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes

To be considered for this study, you generally need to be an adult (18 years or older) and meet certain criteria related to your weight. This means you would either have a Body Mass Index (BMI) of 30 or higher, which is generally considered obesity, or a BMI between 27 and 30, which is considered overweight, but with at least one other health condition linked to weight, like prediabetes or high blood pressure. You also need to have tried to lose weight through diet and exercise in the past without long-term success, and be able to give yourself injections or have someone help you.

There are also some reasons why you wouldn't be able to join. For example, if you have type 1 or type 2 diabetes, or if your obesity is caused by certain other rare medical conditions. You also can't have had major weight loss surgery in the past or be planning to have one. Conditions like recent heart problems, certain stomach issues, or poorly controlled high blood pressure would also mean you can't take part. The research team will carefully check all these details with you.

If you decide to take part in this study, you would be randomly assigned to either receive the study medicine (enicepatide) or a placebo (a dummy medicine). You will be shown how to give yourself the medicine as an injection, or someone trained can help you if needed. Over the course of the study, you would attend regular visits to the clinic so the research team can monitor your health, check for any changes in your weight, and see how you are responding to the treatment. These visits will involve various assessments, which might include blood tests, physical exams, and discussions about how you're feeling. The total time you would be involved in the study would be explained by the research team, but studies like this often last for a year or more. You would also have check-ups after your main treatment period has finished.