Active not recruitingOBSERVATIONAL

Dental Malocclusion and Craniofacial Development in OI

This study is about understanding dental and jaw issues in people with Osteogenesis Imperfecta (OI), often called 'brittle bone disease'. People with moderate to severe OI can have very easily broken bones. They might also have dental problems like discoloured, chipped teeth and difficulty chewing. Treating these dental issues is tough because of the bone quality. Researchers want to thoroughly investigate how OI affects teeth alignment and the shape of the head and neck. By getting a clearer picture of these problems, the main goal is to ultimately improve dental health, which can make a big difference to the quality of life for people living with OI.

At a glance

Status

Active not recruiting

Sponsor

Baylor College of Medicine

Enrolment target

Start

01 Aug 2016

Estimated completion

01 Dec 2027

Osteogenesis Imperfecta

What is this study about?

This study is looking into how Osteogenesis Imperfecta (OI) – a condition that makes bones break very easily – affects people's teeth and jaws. People with moderate to severe OI often have what's called dentinogenesis imperfecta (DI). This means their teeth can be grey or brown, chip easily, wear down quickly, and break. They might also have problems with the shape of their skull and neck. These issues can lead to very crooked teeth, making it hard to chew food properly. Because of the bone problems in OI, fixing these dental issues can be very challenging.

The main aim of this research is to understand these dental and jaw problems better. The more we know, the better doctors can help people with OI. Ultimately, the study hopes to find ways to improve dental health, which can significantly boost the overall quality of life for those with the condition.

To do this, the researchers will carefully examine information from people with OI. They'll look at past study results and take new scans of participants' mouths and jaws. This will help them describe exactly what kind of teeth misalignment and head/neck changes are happening in people with moderate to severe OI.

Key takeaways

This study focuses on dental and jaw issues in people with Osteogenesis Imperfecta (OI).
It aims to improve dental health and quality of life for those with OI.
Participation involves x-rays and scans of your mouth and jaw over three years.
You must already be in the Brittle Bone Disease Longitudinal Study to join.
It's for people aged 10 to 100 with certain types of OI (not Type 1).
You can withdraw from the study at any time.

Who may be eligible?

To join this study, you need to have a diagnosis of Osteogenesis Imperfecta (OI), but not Type 1 OI. You also need to be 10 years old or older. You must already be taking part in a different study called the Brittle Bone Disease (BBD) Longitudinal Study (study number 7701).

There are a few reasons why someone might not be able to join. For example, if it's not possible to position you correctly for x-rays, perhaps due to severe spine curvature or a very short neck, you wouldn't be able to take part. Also, women who are pregnant cannot join this study.

This study is open to both men and women between the ages of 10 and 100.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Do you have Osteogenesis Imperfecta (OI), but not Type 1?
Are you 10 years old or older?
Are you already taking part in the Brittle Bone Disease (BBD) Longitudinal Study (7701)?
Are you able to lie still for X-rays and scans?
Are you a woman who is not pregnant?

Answer every question to see your result.

What does participation involve?

If you decide to take part, the researchers will use information from previous evaluations you've had as part of the Brittle Bone Disease (BBD) Longitudinal Study. You will also have some new tests. These include several x-rays, a special 3D scan of your mouth, and a Cone Beam CT scan of your jaw. These scans will happen at the beginning of the study, and then again after three years. The good news is that these study visits can often be scheduled to happen at the same time as your regular visits for the BBD Longitudinal Study, making it more convenient for you. The total duration of your active participation will be three years.

Potential risks and benefits

Potential benefits of taking part include contributing to a better understanding of dental and jaw problems in OI, which could lead to improved care for yourself and others in the future. The risks involve radiation exposure from the x-rays and CT scan, although the research team will ensure these are kept as low as reasonably possible. There is also the inconvenience of attending study visits. You are free to withdraw from the study at any time without giving a reason, and this will not affect your usual medical care.

Locations (3)

University of California Los Angeles
Verified postcode
Los Angeles, United States
Baylor College of Medicine
Verified postcode
Houston, United States
Shriners Hospital for Children
Verified postcode
Montreal, Canada

Common questions

What is Osteogenesis Imperfecta (OI)?

OI is a rare inherited condition that makes your bones break very easily, sometimes called 'brittle bone disease'.

What are 'dentinogenesis imperfecta' (DI) and dental malocclusion?

DI means teeth might be discoloured, chipped, or wear down easily. Dental malocclusion means your teeth are misaligned or crooked, which can make chewing difficult.

Why is this study important?

It aims to understand these dental and jaw problems better so that doctors can find ways to improve dental health and overall quality of life for people with OI.

What tests will I have if I join?

You'll have several x-rays, a 3D scan of your mouth, and a special jaw CT scan at the start and after three years.

Can I still participate if I'm not in the Brittle Bone Disease (BBD) Longitudinal Study?

No, a key requirement is that you must already be a participant in the BBD Longitudinal Study (study number 7701).