A Trial to Learn How Safe AZD9550 Monotherapy and Combined With AZD6234 is in People With or Without Type 2 Diabetes Who Are Living With Obesity and Overweight
This research is investigating two new medicines, AZD9550 and AZD6234, for people who are overweight or living with obesity. It includes people with and without Type 2 diabetes. The main goals are to check how safe these medicines are, how well people tolerate them, and how they behave in the body. Researchers are testing AZD9550 by itself and then in combination with AZD6234. Understanding how these medicines are absorbed, used, and removed by the body is also a key part of the study. This is an early-stage study, meaning it's one of the first times these specific treatments are being tested in people for these conditions.
At a glance
What is this study about?
This study is looking into new ways to help people who are overweight or living with obesity. It's focused on two new medicines, AZD9550 and AZD6234. Sometimes, people living with obesity also have Type 2 diabetes, and this study includes both groups.
The main aim is to understand if these medicines are safe and how well people can take them. Researchers will also figure out how the body uses, breaks down, and gets rid of these medicines. They will test AZD9550 on its own at different amounts, and then combine it with AZD6234. Some people will also receive a dummy treatment (placebo) to help researchers understand if any changes are due to the treatment itself or something else.
This is a clinical trial, which means it helps us learn more about potential new treatments. The information gathered will be used to see if these medicines could be helpful in the future for managing overweight and obesity, and related health problems.
Key takeaways
- This study explores new treatments for overweight and obesity.
- It includes people with and without Type 2 diabetes.
- The main goals are to check safety and how the medicines work in the body.
- You will receive either the investigational medicine or a placebo.
- Regular health checks and blood tests are part of participation.
- You can withdraw from the study at any time.
Who may be eligible?
This study is looking for both men and women. For some parts of the study, you need to be between 18 and 65 years old, while for other parts, the age range extends up to 75 years old.
Your body weight is also important. Depending on the specific part of the study, your Body Mass Index (BMI) needs to be at least 27, or at least 30. We are looking for people who are overweight or living with obesity.
You might be included whether or not you have Type 2 diabetes. If you do have Type 2 diabetes, your blood sugar levels (HbA1c) need to be within a certain range, and you might need to adjust your current diabetes medications before joining. For example, if you're taking certain diabetes medicines, you might need a 'washout' period where you stop taking them for a few weeks before the study begins.
Could this study suit you?
Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.
- Are you between 18 and 75 years old?
- Are you overweight or living with obesity (check your BMI)?
- Are you willing to potentially stop some of your current diabetes medicines if needed?
- Are you comfortable with receiving medicines by injection?
- Are you willing to attend regular study appointments?
- Can you provide informed consent to participate?
What does participation involve?
Taking part in this study means you would receive either the new medicine (AZD9550, alone or with AZD6234) or a dummy treatment (placebo). The medicines are given as injections under the skin. The study is organised into different 'parts' (A-F), and what you do will depend on which part you're in.
You will have regular appointments where doctors and nurses will check your health, measure your weight, and take blood samples. This helps them see how your body is reacting to the medicine and if there are any side effects. These visits will involve various tests and checks to monitor your safety and how the medicine is working. The exact number of visits and the total length of your participation will depend on the specific part of the study you join, but clinical trials usually involve several visits over several weeks or months.
Potential risks and benefits
Locations (15)
- Research SiteVerified postcodeGraz, Austria· Completed
- Research SiteVerified postcodeVienna, Austria· Completed
- Research SiteVerified postcodeSurrey, Canada· Recruiting
- Research SiteVerified postcodeHamilton, Canada· Recruiting
- Research SiteVerified postcodeSarnia, Canada· Recruiting
- Research SiteVerified postcodeStouffville, Canada· Recruiting
- Research SiteVerified postcodeToronto, Canada· Recruiting
- Research SiteVerified postcodeSherbrooke, Canada· Completed
- Research SiteVerified postcodeMagdeburg, Germany· Active not recruiting
- Research SiteVerified postcodeNeu-Ulm, Germany· Active not recruiting
- Research SiteVerified postcodeNeuss, Germany· Active not recruiting
- Research SiteVerified postcodeFukuoka, Japan· Completed
Common questions
What is a 'placebo' in this study?
A placebo is a dummy treatment that looks just like the real medicine but contains no active drug. It helps researchers see if the actual medicine is causing a change or if it's due to other factors.
Will I know if I'm getting the real medicine or the placebo?
No, this is a 'single-blind' study, meaning you won't know if you're getting the active drug or the placebo. This helps ensure the results are fair and unbiased.
What does 'monotherapy' mean?
'Monotherapy' means you would receive just one of the investigational medicines, AZD9550, by itself.
What if I'm already taking medication for my Type 2 diabetes?
Depending on your current diabetes medications, you might need to stop taking some or all of them for a period before you can join the study. The study team will advise you on this.
How will the medicines be given?
The medicines being tested in this study will be given as injections under the skin.
How to find out more
AstraZeneca Clinical Study Information Center
Always speak to your GP or specialist before deciding to take part in a study.
Interested in taking part?
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