AuthorisedTherapeutic confirmatory (Phase III)Interventional

A 52-week multicenter, randomized, parallel-group trial in overweight people investigating lifestyle changes, mushroom supplementation and bupropion to reduce adiposity and cardiometabolic risk

Carrying extra weight can increase the risk of health issues such as high blood pressure, high cholesterol, and type 2 diabetes. This 52-week clinical study is investigating whether a medicine named bupropion, combined with lifestyle support and a mushroom food supplement, can help adults safely lose weight and improve their overall health. Researchers want to see how much weight participants lose over six months and whether these benefits continue for a full year. They will also track improvements in blood pressure, blood fats, and blood sugar. The trial is open to adults aged 18 and over who have a body mass index (BMI) between 25 and 34.9. Joining the study is entirely voluntary, and participants receive regular health checks and close medical supervision throughout the trial.

At a glance

Status

Authorised

Phase

Therapeutic confirmatory (Phase III)

Sponsor

Uppsala University

Enrolment target

250

Start

21 Aug 2026

Overweight or class I obesity (BMI 25.0–34.9 kg/m²), with or without cardiometabolic risk factors (hypertension, hyperlipidemia, and/or prediabetes).

What is this study about?

Many adults find it challenging to lose weight and keep it off through diet and exercise alone. Extra body weight, especially around the waist, can place extra strain on the heart and blood vessels. Over time, this can raise the risk of developing conditions like heart disease, high blood pressure, and type 2 diabetes. Researchers are constantly looking for safe, effective ways to support people in reaching a healthier weight.

This clinical study is exploring a combined approach. It tests whether taking a medicine called bupropion, alongside lifestyle support and a mushroom supplement, can help people reduce body fat. Bupropion is a prescription medicine that can affect appetite and cravings. The researchers want to see if combining this treatment with healthy habit changes helps people lose weight more effectively than usual methods.

The trial will run for 52 weeks (one year). By tracking participants' weight and checking their blood pressure, blood sugar, and cholesterol levels, the study team hopes to learn whether this treatment can lower key health risks. If successful, the results could give doctors new options to help people manage their weight and protect their future health.

Key takeaways

The study tests whether the medicine bupropion, lifestyle support, and mushroom supplements help with weight loss.
It lasts for 52 weeks and is designed for adults aged 18 and over.
Participants must have a BMI between 25.0 and 34.9 kg/m².
Researchers will check changes in body weight, blood pressure, cholesterol, and blood sugar.
Taking part is completely voluntary and includes regular medical check-ups.

Who may be eligible?

This study is open to men and women aged 18 and older who are classified as overweight or having mild obesity. This means having a body mass index (BMI) between 25.0 and 34.9 kg/m².

You may be able to join whether you currently have related health conditions or not. The researchers are interested in participants who have normal health markers, as well as those who have early signs of heart or metabolic concerns, such as slightly raised blood pressure, high cholesterol, or prediabetes.

Because safety is the top priority, there may be certain reasons why someone cannot join, such as specific medical conditions, allergies, or other medications they are taking. The study team will review your full medical history to make sure taking part is safe for you.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

I am aged 18 or older.
My BMI is between 25.0 and 34.9 kg/m² (overweight or mild obesity).
I am interested in receiving lifestyle advice and taking study treatments for one year.
I am able to attend regular clinic visits for weight and health checks.
I am willing to undergo routine health assessments, such as blood pressure and blood tests.

Answer every question to see your result.

What does participation involve?

Taking part in this study lasts for 52 weeks (about one year). If you decide to join, you will be assigned to a treatment plan that includes lifestyle guidance, the study medication (bupropion), and dietary supplements. You will need to take the study treatments as directed and attend regular check-ups at a study clinic. During these visits, doctors and nurses will monitor your health closely. Assessments will include checking your weight, measuring your waist, taking your blood pressure, and having routine blood tests to look at your cholesterol and blood sugar levels. You will also have the chance to discuss how you are feeling and report any side effects.

Potential risks and benefits

Taking part may help you lose weight and could improve your blood pressure, cholesterol, or blood sugar levels. You will also receive regular health checks and support from a medical team. However, as with any medicine, bupropion can cause side effects, which the study doctor will explain before you agree to take part. There is also a time commitment needed for clinic visits and health tests. Your participation is completely voluntary, and you are free to leave the trial at any time without giving a reason and without it affecting your standard NHS care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

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Unverified
Sweden

Common questions

What is bupropion?

Bupropion is a prescription medicine that affects certain chemical messengers in the brain. It is sometimes used to help manage mood or to help people stop smoking, and researchers are studying how it may help with appetite and weight management.

Do I have to pay to take part in this study?

No, you do not need to pay for any study medications, supplements, or medical tests carried out as part of the clinical trial.

Will taking part guarantee that I lose weight?

No clinical trial can guarantee results. Everyone's body responds differently to treatments, which is why clinical trials are needed to see how well the approach works.

Can I leave the trial if I change my mind?

Yes. Joining is entirely your choice, and you can stop participating at any point. Leaving will not change your regular healthcare or your relationship with your doctor.

Does this trial replace my normal GP appointments?

No. The trial team will focus only on the study and your safety within it. You should continue seeing your GP for any other routine healthcare needs or ongoing conditions.