Ongoing, recruitingHuman Pharmacology (Phase I)- OtherInterventional

A study investigating the safety of RO7795074, a new compound that may potentially be used in the treatment of type 1 diabetes, and the effect of RO7795074 on how the body processes pitavastatin

This is an early-stage study testing a new medicine, RO7795074, that could one day help people with type 1 diabetes. Researchers want to make sure it's safe for people to take. They are also checking how RO7795074 interacts with another medicine called pitavastatin, which is used to lower cholesterol. This study is for healthy adults aged 18 and over who are overweight or obese. It's important to understand how new medicines work in the body and if they are safe before they can be used more widely. This type of research helps doctors learn more about potential treatments.

At a glance

Status

Ongoing, recruiting

Phase

Human Pharmacology (Phase I)- Other

Sponsor

Genentech Inc.

Enrolment target

Start

01 Dec 2025

Overweight or Obese (otherwise healthy)

What is this study about?

This research study is about a new medicine called RO7795074. Scientists are hoping this medicine could help people who have type 1 diabetes in the future. Right now, this study is in an early stage, which means they are mainly focused on finding out if the medicine is safe when given to people.

They also want to understand how RO7795074 behaves in the body, especially when someone is also taking another common medicine called pitavastatin. Pitavastatin is often prescribed to help lower cholesterol. Sometimes, different medicines can affect how each other work, and it's very important for doctors to know about these interactions to keep patients safe.

This study includes healthy adults who are overweight or obese. This allows researchers to focus on the medicine's safety and how it interacts with pitavastatin, without other health conditions making the results harder to understand. The information gathered from this study will be a vital step in deciding if RO7795074 can move forward to bigger studies and potentially help people with type 1 diabetes.

Key takeaways

This is an early study testing a new medicine (RO7795074) for type 1 diabetes.
The main goals are to check the medicine's safety and how it interacts with pitavastatin.
It's for healthy adults who are overweight or obese.
Participation would involve clinic visits, medication, and health checks.
Your involvement helps advance medical knowledge for future treatments.
You can always choose to leave the study at any point.

Who may be eligible?

This study is looking for healthy adults, which means you shouldn't have any major ongoing health problems. You need to be at least 18 years old, and there isn't an upper age limit mentioned.

Participants in this study should be overweight or obese. This doesn't mean you need to have a specific weight, but rather fall within a certain range based on your height and weight, often called your Body Mass Index (BMI).

Both men and women are welcome to take part in this study. The research team will do medical checks to make sure you're healthy enough for the study.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Do you consider yourself generally healthy, without major ongoing health conditions?
Are you overweight or obese according to standard health guidelines (e.g., BMI)?
Are you able to commit to several appointments at a clinic or research centre?

Answer every question to see your result.

What does participation involve?

If you decide to take part, you would likely have several visits to a clinic or research centre. These visits would involve health checks, such as blood tests, urine tests, and monitoring your heart. You would be given the study medicine, RO7795074, and possibly pitavastatin as well, following a specific schedule. You'll need to follow instructions carefully about taking the medicines and any dietary restrictions. The exact number of visits, tests, and the total length of time you'd be involved aren't detailed here but would be explained fully before you join.

Potential risks and benefits

Taking part in any study has potential benefits and risks. A potential benefit of this study is helping researchers learn more about a new medicine that could one day help people with type 1 diabetes. You might also receive regular health checks. However, there could be side effects from the new medicine, and doctors don't know all of these yet. There might also be discomfort from blood tests or other procedures. You have the right to withdraw from the study at any time, for any reason, without it affecting your medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

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Unverified
Netherlands

Common questions

What is type 1 diabetes?

Type 1 diabetes is a long-term condition where the body's immune system mistakenly attacks and destroys the cells in the pancreas that produce insulin, a hormone essential for controlling blood sugar.

What does 'Phase I' mean for a study?

Phase I is the earliest stage of human testing for a new medicine. It mainly focuses on whether the medicine is safe, what dose is best, and how it acts in the body, usually in a small group of healthy volunteers.

What is pitavastatin?

Pitavastatin is a medicine commonly prescribed to help lower high cholesterol levels in the blood, which can reduce the risk of heart disease.

Why include only overweight or obese healthy people?

This helps researchers focus on how the new medicine works and its safety without other existing health problems complicating the results. It's a common approach in early-stage studies.

Will I get paid for taking part?

The information provided doesn't say if participants will be paid. This is a good question to ask the study team if you are interested.