RecruitingOBSERVATIONAL

Pancreatic Cancer Early Detection Consortium

This research project, called the Pancreatic Cancer Early Detection Consortium (PRECEDE), is looking for better ways to find pancreatic cancer early and prevent it. It focuses on people who have a higher chance of developing pancreatic cancer, either because it runs in their family or they have certain genetic changes. The study will collect health information and samples like blood over time (every 6-12 months). By carefully studying these samples and health records, the researchers hope to learn more about how pancreatic cancer starts and find new ways to detect it sooner. Your doctor will continue to provide your usual care throughout the study.

At a glance

Status

Recruiting

Sponsor

Arbor Research Collaborative for Health

Enrolment target

20,000

Start

18 Sep 2020

Estimated completion

31 Dec 2030

Pancreas Cancer Pancreas Cyst Pancreatic Ductal Adenocarcinoma Genetic Predisposition

What is this study about?

This research is focused on a type of cancer called pancreatic cancer. It's a serious condition, and finding it early can make a big difference. That's why this study, called the PRECEDE study, is so important. Its main goal is to find better ways to spot pancreatic cancer as early as possible and, hopefully, even prevent it in some cases. Scientists are particularly interested in people who might have a higher risk, such as those with a family history of pancreatic cancer or those who have specific changes in their genes that are linked to an increased risk.

To achieve this, the PRECEDE study is bringing together information from many different medical centres. They are creating a large group of people who are at higher risk. By following these individuals over time, probably for many years, and regularly collecting health information and samples like blood, the researchers hope to learn more about the very early signs of pancreatic cancer. They want to understand how it develops.

All the samples collected will be handled and stored in a very careful, standardised way. The information from your medical records will also be used to help the researchers understand how it connects with the lab results from your samples. This big picture will help scientists develop new tests or methods for early detection, which could ultimately save lives. Your participation helps build this important knowledge base, and your own medical care will continue as normal with your doctor throughout the study.

Key takeaways

This study aims to find better ways to detect pancreatic cancer early.
It focuses on people with a higher risk due to family history or specific genetic changes.
Participation involves regular visits for blood tests and sharing health information.
It is an observational study, so you won't receive new treatments.
Your regular medical care will continue as usual.
Helping this research could benefit future patients.

Who may be eligible?

This study is looking for adults aged 18 to 90 years old, both men and women, who are at a higher risk of developing pancreatic cancer but don't currently have it.

You might be eligible if you have a strong family history of pancreatic cancer, for example, if two or more close relatives on the same side of your family have had it. You could also be eligible if you have specific genetic changes that doctors know are linked to an increased risk of pancreatic cancer, even if you don't have a strong family history. Some rarer genetic conditions also make people eligible.

There are different groups within the study, and the exact requirements for age and family history can vary slightly between these groups. Importantly, if you don't meet the exact age or family history requirements for the main groups but are still considered at high risk by your doctor, you might still be able to join. The best way to find out if you qualify is to talk to your doctor or the study team.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you between 18 and 90 years old?
Do you not currently have pancreatic cancer?
Do at least two close relatives on the same side of your family have a history of pancreatic cancer?
Do you have a known genetic change (like in BRCA1, BRCA2, or ATM genes) linked to higher pancreatic cancer risk?
Has a doctor told you that you are at a higher risk of pancreatic cancer?

Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, you will be asked to visit your clinic usually every 6 to 12 months. During these visits, doctors will collect blood samples from you. There's a standard way they collect and process these samples to make sure all information is consistent across different study sites. These samples will be stored carefully for future research.

As part of the study, researchers will also look at your existing medical records and health information. This helps them connect your health history with the results from the samples. You won't be given any new medications or treatments as part of this study, as it's an 'observational' study – meaning doctors are observing and collecting information, not giving new treatments. Your regular doctor will continue to manage your care as they normally would after any procedures you might have.

The overall length of your participation is not specified, but these types of studies often follow participants for many years to track changes over time. Your commitment would involve these regular visits for sample collection and allowing access to your medical information for research purposes.

Potential risks and benefits

Taking part in this study does not involve any direct medical treatment or intervention, so the risks are generally low. The main risks would be those associated with routine blood draws, such as slight pain, bruising, or a very small chance of infection at the injection site. Your personal information will be kept confidential and protected. While there may not be immediate personal benefits, the information gathered from your participation could help researchers develop better early detection methods for pancreatic cancer in the future, potentially benefiting many others. You are free to withdraw from the study at any time, for any reason, without it affecting your medical care.

Locations (60)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

Mayo Clinic Arizona
Verified postcode
Phoenix, United States· Not yet recruiting
Honor Health Research Institute
Verified postcode
Scottsdale, United States· Recruiting
Providence Health and Services
Verified postcode
Burbank, United States· Recruiting
City of Hope
Verified postcode
Duarte, United States· Recruiting
UC San Diego Moores Cancer Center
Verified postcode
La Jolla, United States· Recruiting
Cedars-Sinai Medical Center
Verified postcode
Los Angeles, United States· Recruiting
UCLA Health
Verified postcode
Los Angeles, United States· Recruiting
Hoag
Verified postcode
Newport Beach, United States· Recruiting
UC Irvine Health
Verified postcode
Orange, United States· Recruiting
UC Davis
Verified postcode
Sacramento, United States· Recruiting
University of California, San Francisco (UCSF)
Verified postcode
San Francisco, United States· Recruiting
Yale University
Verified postcode
New Haven, United States· Recruiting

Common questions

What is pancreatic cancer?

Pancreatic cancer is a disease where cells in the pancreas, an organ behind the stomach, grow out of control. It can be hard to spot early.

What does 'early detection' mean?

Early detection means finding a disease like cancer at its very first stages, often before symptoms appear, when it is usually easier to treat.

Will this study give me treatment?

No, this is an 'observational' study. You won't receive new treatments or medicines through the study. Your current medical care will continue as normal.

What is a 'genetic change'?

A genetic change, or 'variant', is a difference in your DNA that can sometimes increase your risk for certain health conditions, like some cancers.

How often would I need to visit?

You would typically need to visit your clinic every 6 to 12 months for sample collection and health check-ups related to the study.

How to find out more

Naveen Fawas, BS

naveen.fawaz@arborresearch.org 7346654108 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.