Adjuvant Trial in Patients With Resected PDAC Randomized to Allocation of Oxaliplatin- or Gemcitabine-based Chemotherapy by Standard Clinical Criteria or by a Transcriptomic Treatment Specific Stratification Signature

This study is looking for both men and women between the ages of 18 and 79 who have been diagnosed with pancreatic cancer that has been successfully removed by surgery. It's important that your general health is good enough to receive chemotherapy, meaning you can eat well, aren't suffering from severe nausea, and your blood test results (like your blood counts and kidney function) are in a healthy range.

You wouldn't be able to join if your cancer had spread to distant parts of your body, or if the surgeon hadn't been able to remove all of the cancer visible during the operation. Also, if you've already had chemotherapy or radiotherapy for your pancreatic cancer, this study wouldn't be suitable for you. You also need to have recovered well from your surgery and be ready to start chemotherapy within 3 to 12 weeks after your operation.

If you're a woman who could become pregnant, you'd need to use effective contraception throughout the study and for 6 months afterwards. Men would also need to use contraception for 6 months after their last treatment. It's really important that you understand what's involved in the study and are willing to give your written permission to take part.

If you join this study, your journey will begin after your pancreatic cancer surgery, usually within 3 to 12 weeks. You'll be assigned by chance to one of two groups: either your chemotherapy will be chosen using standard medical guidelines, or it will be chosen based on a special genetic test of your tumour. Both groups will receive a standard chemotherapy regimen, either oxaliplatin-based (like FOLFOX or FOFLIRI) or gemcitabine-based (like Gemcitabine alone or with Capecitabine).

You will have regular hospital visits to receive your chemotherapy treatments and for check-ups and monitoring your health. These visits will typically involve blood tests and physical examinations. The total duration of your active chemotherapy treatment will depend on the specific regimen you receive, but you will be followed up for several years after completing treatment to see how you are doing, usually with scans and check-ups. You might also be asked to provide additional tumour tissue and blood samples for research purposes at specific times.