RecruitingOBSERVATIONAL

Periprosthetic Fracture Registry (PPFx)

This registry is collecting important information about how we treat bone breaks that happen around hip or knee replacement joints. These types of breaks are called periprosthetic fractures. We want to understand which treatments work best, what causes them, and how rehabilitation helps. By gathering details from many patients across different hospitals, we aim to improve how these injuries are treated, make care safer, and help patients recover better. The information collected will also guide future research into new and improved treatments and surgical methods. Ultimately, this will lead to better outcomes for patients with these types of fractures.

At a glance

Status

Recruiting

Sponsor

AO Innovation Translation Center

Enrolment target

600

Start

31 Dec 2018

Estimated completion

31 Mar 2027

Periprosthetic Fractures Periprosthetic Fracture Around Prosthetic Joint Implant

What is this study about?

Imagine you've had a hip or knee replacement, and unfortunately, a bone breaks near that artificial joint. This is called a periprosthetic fracture. Doctors are always working to find the best ways to treat these breaks, but there's still a lot to learn about what works well for different people.

This study isn't testing a new medicine or treatment. Instead, it's like a big information gathering project, called a registry. It's collecting details from many hospitals around the world about patients who have had these bone breaks and how they were treated. Think of it as a shared notebook where doctors write down how they fixed the break, what type of implant they used, and how the patient recovered. This helps build a clearer picture of what's happening.

The main goal is to understand several things: Does the type of implant used make a difference? Do certain surgical methods work better? Are some people more at risk of these breaks than others? Does the rehabilitation after surgery affect recovery? By answering these questions, this registry will help doctors make better choices about how to treat these fractures, improve patient safety, and potentially reduce the number of complications. It will also help guide future research to develop even better treatments.

Ultimately, by learning from many patients' experiences, this study aims to improve care for everyone who experiences a bone break around a hip or knee replacement in the future. It's about making sure doctors have the best possible information to treat these complex injuries.

Key takeaways

This study collects information, it's not a new treatment.
It aims to improve care for bone breaks around hip and knee replacements.
Your personal details will be kept private and anonymous.
It helps doctors understand which treatments work best.
You only need to agree to share your medical records.
Your participation helps future patients.

Who may be eligible?

To be part of this information-gathering project, you need to be at least 18 years old.

Crucially, you would have had a bone break (a periprosthetic fracture) around an existing hip or knee replacement. This means the break happened after your original joint replacement surgery. The break could be in the hip socket, thigh bone, kneecap, or shin bone near the joint. The treatment for your break must have involved either fixing the bone with plates/nails (osteosynthesis) or replacing parts of your joint and also fixing the bone.

Before joining, you'd need to understand what the project involves and agree to share your information by signing a consent form. You also need to be able to attend your regular follow-up appointments after your surgery.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Have you had a bone break around a hip or knee replacement?
Was your break treated with surgery (e.g., plates, screws, or component replacement)?
Are you able to attend your usual follow-up appointments?
Are you willing to understand and sign a consent form?

Answer every question to see your result.

What does participation involve?

If you are eligible and agree to take part, your doctor will collect information about your bone break, the surgical procedure you had (including the type of implants or techniques used), and how you recover afterwards. This information will come from your medical records and your regular check-up visits. You won't be asked to take any new medicines or have extra tests just for this project. The information collected will simply be part of your usual care. The project will follow your progress through your routine follow-up appointments.

Potential risks and benefits

There are no direct risks to you by participating in this data registry because it only involves collecting information from your existing medical records and routine follow-up appointments. There are also no direct personal benefits. However, by allowing your de-identified medical information to be included, you will be contributing to a larger effort to improve treatments and outcomes for future patients who experience similar bone breaks. You are free to withdraw your consent and stop sharing your data at any time without affecting your medical care.

Locations (13)

University of Missouri Health Care
Verified postcode
Columbia, United States· Recruiting
Jersey City Medical Center RWJ Barnabas Health
Verified postcode
Jersey City, United States· Recruiting
Saint Barnabas Medical Center Livingston
Verified postcode
Livingston, United States· Recruiting
Vanderbilt University Medical Center
Verified postcode
Nashville, United States· Recruiting
Universitaire Ziekenhuiven Leuven
Verified postcode
Leuven, Belgium· Recruiting
Hospital Santa Clara
Verified postcode
Bogotá, Colombia· Recruiting
Charité Universitätsmedizin Berlin
Verified postcode
Berlin, Germany· Recruiting
BG-Unfallklinik Ludwigshafen
Verified postcode
Ludwigshafen, Germany· Recruiting
Universitätsklinikum Münster
Verified postcode
Münster, Germany· Recruiting
Hospital Universitario Son Llàtzer
Verified postcode
Palma de Mallorca, Spain· Recruiting
Universitätsspital Basel
Verified postcode
Basel, Switzerland· Recruiting
Kantonspital Baselland
Verified postcode
Liestal, Switzerland· Terminated

Common questions

What is a 'periprosthetic fracture'?

It's a broken bone that happens around an artificial hip or knee joint that you've had replaced.

Am I being given a new medicine or treatment?

No, this study isn't testing new treatments. It's collecting information about the treatments you've already received as part of your standard care.

Will my personal details be shared?

No, all your personal information is kept private. The study only uses anonymised details about your medical condition and treatment, so no one can identify you.

Why is this information important?

By looking at many patients' information, doctors can learn which treatments work best, identify risks, and improve care for people with these types of fractures in the future.

What do I need to do if I take part?

You just need to agree to share information from your medical records and attend your normal follow-up appointments. No extra visits or tests are required.

How to find out more

Marco Minoia

marco.minoia@aofoundation.org +41 79 612 09 67 Official trial record

Always speak to your GP or specialist before deciding to take part in a study.