AuthorisedPhase I and Phase II (Integrated)- OtherInterventional

LAMP-COVID: Locating Amyloid-containing Microclots with total-body PET in post-COVID syndrome

The LAMP-COVID study is investigating a possible cause of long COVID: tiny blood clots, called microclots, that contain a protein called amyloid. We believe these microclots might be involved in the ongoing symptoms many people experience after having COVID-19. This study uses a special imaging technique called a PET scan, along with a tracing substance called FLUTEMETAMOL, to help us find and measure these microclots throughout the body. By doing this, we hope to understand if the amount and size of these microclots are linked to the severity of long COVID symptoms. This research could help us learn more about long COVID and potentially lead to new ways to diagnose or treat it in the future.

At a glance

Status

Authorised

Phase

Phase I and Phase II (Integrated)- Other

Sponsor

Amsterdam UMC Stichting

Enrolment target

Start

07 May 2026

post-COVID syndrome (long COVID)

What is this study about?

Many people who have had COVID-19 continue to experience a range of symptoms, such as tiredness, breathlessness, and 'brain fog', long after the initial infection has passed. This is known as post-COVID syndrome, or long COVID. Scientists are still working to understand exactly why some people develop long COVID and what might be causing these persistent symptoms.

One idea is that tiny blood clots, much smaller than typical blood clots, might be playing a role. These are called 'microclots' and some studies suggest they contain a specific protein called amyloid. The LAMP-COVID study aims to investigate this further. We are using a special type of scan, called a PET scan, to look for these amyloid-containing microclots throughout the body of people with long COVID. A safe, slightly radioactive substance called FLUTEMETAMOL is used during the scan to highlight these microclots, allowing researchers to see and measure them.

The main goal of this study is to accurately measure where these microclots are in the body and how much FLUTEMETAMOL binds to them. We will also compare these measurements with participants' long COVID symptoms, and look at brain scans (MRI) to see if there's a link between microclots, symptoms, and changes in brain structure or function. By doing this, we hope to gain a much clearer picture of whether these microclots are directly involved in long COVID symptoms.

Key takeaways

This study investigates if tiny blood clots (microclots) are linked to long COVID symptoms.
It uses a special PET scan and a tracer (FLUTEMETAMOL) to find and measure these microclots.
The study aims to understand the connection between microclots and long COVID symptoms severity.
You won't receive new long COVID treatments, but you'll contribute to important research.
Participation involves scans, blood tests, and questionnaires.
You can withdraw from the study at any time without affecting your medical care.

Who may be eligible?

To take part in this study, you must be 18 years old or older. The study is open to both men and women.

The research team will need to check your medical history to make sure taking part is safe for you and that you meet all the study's requirements. This often includes reviewing your current health conditions and any medications you are taking.

Because this study uses a special tracing substance for the PET scan, there might be other specific health conditions or medications that would prevent you from joining. The study team will discuss all of these details with you thoroughly.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Do you have post-COVID syndrome (long COVID)?
Are you comfortable having blood tests and medical scans (like PET and MRI)?
Are you willing to discuss your full medical history with the study team?
Are you able to travel to the study site for appointments?

Answer every question to see your result.

What does participation involve?

If you decide to take part, you would likely have a few visits to a clinic or hospital for assessments and scans. These visits may include answering questionnaires about your long COVID symptoms, having blood tests to look for microclots, and undergoing MRI brain scans. The main part of the study involves a PET scan, where you will receive a small injection of the FLUTEMETAMOL tracing substance before the scan. This substance helps highlight the microclots for the imaging.

Each visit will have a clear schedule, and staff will guide you through each step. There isn't a long-term 'follow-up' period in the same way some drug trials have; this study is focused on the measurements at specific time points. The total time you would be involved in the study, from your first screening appointment to your last study visit, will be explained to you by the research team. You won't be given any new medications or treatments for long COVID as part of this study, as it's an observational imaging study.

Potential risks and benefits

Participating in this study might provide you with a clearer understanding of your long COVID and contribute to important scientific knowledge that could help future patients. However, there is no guarantee that you will personally benefit from taking part. Potential risks include discomfort from blood tests and injections, and very low exposure to radiation from the PET scan, similar to what you might experience from natural sources or other medical scans. You will be fully informed about these risks before you agree to participate. Remember, your participation is completely voluntary, and you have the right to withdraw from the study at any time, for any reason, without affecting your medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

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Unverified
Netherlands

Common questions

What is a microclot?

A microclot is a very tiny blood clot, much smaller than typical blood clots that might cause problems like a stroke. Researchers are investigating if these microscopic clots might play a role in long COVID.

What is a PET scan?

A PET scan is a special type of imaging scan that uses a small amount of a safe tracing substance (like FLUTEMETAMOL in this study) injected into your body. This substance helps show how your organs and tissues are working, allowing researchers to see things like microclots.

Will I get any medicine for long COVID in this study?

No, this study is about understanding and measuring microclots, not about giving out new treatments. You will not receive any specific medication for long COVID as part of this research.

Is the FLUTEMETAMOL tracing substance safe?

Yes, FLUTEMETAMOL is a well-studied substance used in medical scans. You will receive a very small, safe amount, and the research team will explain any potential, very rare side effects.

How long will my involvement in the study last?

The study team will tell you the exact time commitment, which will include a few visits for screening, tests, and scans. It's usually not a very long-term commitment, but focused on gathering specific information.