AuthorisedTherapeutic exploratory (Phase II)Interventional

Magnesiumsulphate for Postoperative Analgesia In the Newly delivered, The MAG-PAIN randomized controlled trial.

This study, called MAG-PAIN, is exploring whether magnesium sulfate can help mothers manage pain after giving birth. It focuses on women who have just had a baby and are experiencing pain in the first six hours after delivery. The researchers want to see if magnesium can make a difference in how much pain they feel, both when resting and moving. They will also look at whether it affects things like how quickly mothers recover, if they need less stronger pain medication, and how they feel about breastfeeding and bonding with their baby. This is an early-stage study, meaning it's one of the first times this treatment is being tested for this particular use.

At a glance

Status

Authorised

Phase

Therapeutic exploratory (Phase II)

Sponsor

Region Halland

Enrolment target

150

Start

17 Mar 2025

Postoperative pain

What is this study about?

When you have a baby, especially if you've had a C-section or another procedure, it's very common to feel pain afterwards. Doctors are always looking for the best ways to help manage this pain, making sure mothers can recover comfortably and bond with their babies. Pain can make it harder to move around, breastfeed, and simply enjoy those first precious moments with your newborn.

This study is looking into a medication called magnesium sulfate. Magnesium is a mineral that our bodies need for many things, and it's sometimes used for other medical conditions. In this study, researchers want to see if giving magnesium sulfate can help reduce pain after childbirth, particularly in the first six hours when pain can be most intense. They want to compare it to usual care to find out if it's a helpful addition to pain relief options.

By taking part, you could help doctors understand if magnesium sulfate is a safe and effective way to reduce pain and improve recovery for new mothers. This could potentially lead to better pain management options in the future, making the post-delivery period more comfortable for many women.

Key takeaways

Exploring if magnesium sulfate can help new mothers with pain after childbirth.
Focuses on pain relief in the first hours and days after delivery.
Compares magnesium sulfate to standard pain care.
Looks at recovery, other pain medication use, and breastfeeding.
Helps doctors understand better pain management for new mums.
Participation involves sharing information about your pain and recovery over three months.

Who may be eligible?

This study is looking for women who have recently given birth. To be able to join, you must be at least 18 years old. There is no upper age limit, meaning women of any age over 18 can be considered.

The study is specifically for women, as it focuses on pain experienced after childbirth.

Other specific medical details might also be considered by the study doctors to make sure it's safe for you to take part. This will be discussed fully with you if you are interested.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you a woman who has recently given birth?
Are you 18 years old or older?
Are you experiencing pain after your delivery?
Are you willing to answer questions about your pain and recovery for up to three months?

Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, you would receive either magnesium sulfate or the usual care provided for pain. The treatment would be given in the first few hours after you've had your baby. Researchers would then track your pain levels in the first six hours, as well as at 24 hours, 14 days, and three months after delivery. This would involve answering questions about your pain, both when you are resting and when you move, and how you feel about your recovery and breastfeeding. Your use of other pain medications would also be noted. The study involves keeping in touch with the research team for up to three months after your delivery.

Potential risks and benefits

Taking part in a study like this could potentially offer you improved pain relief after childbirth, or it might help future mothers by providing valuable information about pain management. Every medication, including magnesium sulfate, carries some potential risks or side effects, which the study doctors will explain to you in detail. There is also no guarantee that you will personally benefit from taking part. Remember, you can choose to leave the study at any time, for any reason, without it affecting your usual medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

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Unverified
Sweden

Common questions

What is magnesium sulfate?

Magnesium sulfate is a medicine that contains magnesium, a mineral found naturally in your body. It's being studied here to see if it can help with pain after childbirth.

Will I definitely get magnesium sulfate if I join the study?

Not necessarily. In this type of study, people are usually put into groups by chance (like flipping a coin). One group gets the study treatment (magnesium sulfate), and another group gets the usual care, so researchers can compare the two.

How long will the study follow me?

The study will track your progress and ask you questions about your pain and recovery for up to three months after you've given birth.

Is this a new medicine?

Magnesium sulfate itself is not a new medicine. However, using it specifically for pain relief after childbirth in this way is what the study is investigating.

Can I still breastfeed if I take part?

The study will look at how the treatment might affect breastfeeding and your connection with your baby. The doctors will discuss any concerns you have about breastfeeding with you.