AuthorisedTherapeutic use (Phase IV)Interventional

Comparison of the preventive painkiller effect of etoricoxib and celecoxib after M3M surgery: A randomized, double-masked clinical trial

This research is looking into two different pain relief medications, etoricoxib and celecoxib. The main goal is to find out which one is more effective at stopping pain from developing after a wisdom tooth, specifically the third molar in the lower jaw (M3M), has been taken out. Both medicines are already approved and widely used, but this study wants to see how they directly compare for this specific type of pain prevention. Researchers have an idea that etoricoxib might offer better pain relief after the surgery. By comparing these two drugs, doctors hope to better understand how to manage pain for patients after dental procedures, making recovery more comfortable.

At a glance

Status

Authorised

Phase

Therapeutic use (Phase IV)

Sponsor

Semmelweis University

Enrolment target

Start

22 Jan 2025

postoperative period after mandibular M3 removal

What is this study about?

Imagine you're having a wisdom tooth taken out from your lower jaw. Sometimes, even with painkillers, you can still feel quite a bit of discomfort afterwards. This study is trying to find the best way to prevent that pain from starting in the first place, or at least make it much less severe. They are testing two different pain relief medicines you might already know about: etoricoxib and celecoxib. Both of these are pain relievers that work in a similar way, and they are already used by many people for various types of pain.

The main idea behind this research is to see if one of these medicines is clearly better than the other at stopping pain after this common dental surgery. Researchers are particularly interested in etoricoxib, as they have reason to believe it might be more effective. By carefully comparing these two, doctors can learn more about how to give you the most comfortable experience possible after your surgery.

This is called a 'randomized, double-masked' study. 'Randomized' means that if you join, you'll be put into one of the treatment groups by chance, like flipping a coin. 'Double-masked' means neither you nor your doctor will know which medicine you're taking until the study is over. This helps make sure the results are fair and unbiased. Because these medicines are already in use, this study is focusing on their 'therapeutic use' – essentially, how well they work in a real-world setting for this specific purpose.

Key takeaways

Compares two common pain relievers (etoricoxib and celecoxib).
Aims to find the best pain prevention after lower wisdom tooth removal.
Researchers expect etoricoxib might be more effective.
Study involves taking medication before and after surgery.
Participation helps improve future pain management for others.

Who may be eligible?

To be part of this study, you need to be an adult, 18 years old or older. There is no upper age limit, meaning people of any older age can potentially join.

Both men and women are welcome to take part in this research.

The main requirement is that you are scheduled to have a wisdom tooth (the third molar, often called M3) removed from your lower jaw. You'll need to be generally healthy enough for this type of surgery and for taking the study medications.

Could this study suit you?

Answer these quick questions to see if you may be eligible. This is a guide only — the research team makes the final call.

Are you 18 years old or older?
Are you scheduled to have a wisdom tooth (M3) removed from your lower jaw?
Are you generally in good health?
Are you willing to take study medication and attend follow-up checks?

Answer every question to see your result.

What does participation involve?

If you decide to take part in this study, here's generally what you can expect:

Before your surgery, you'll have an initial appointment where doctors will check if the study is right for you. If you qualify, you'll be given one of the study medications (etoricoxib or celecoxib) to take a little while before your wisdom tooth extraction. You won't know which one it is.

After your surgery, you'll continue to take the study medication as instructed for a short period. You'll likely be asked to keep a simple record of any pain you feel and how you're generally doing. There will be at least one follow-up visit or call to see how you're recovering and if you had any side effects. The total duration of your active participation will likely only be a few days around your surgery and recovery.

Potential risks and benefits

Taking part in this study might offer you the benefit of receiving a pain medication that could be more effective at preventing or reducing your pain after wisdom tooth removal. Since the medicines are already approved, serious side effects are rare and well-understood; however, like all medicines, they can have potential side effects, which will be fully explained to you. You are free to withdraw from the study at any time, for any reason, without it affecting your usual medical care.

Locations (1)

Some site locations are approximate. We're improving this — please verify with the trial team before travelling.

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Unverified
Hungary

Common questions

What is a 'wisdom tooth' (M3M)?

It's your third molar, the very back tooth in your mouth, which often needs to be removed from the lower jaw.

What do the medicines etoricoxib and celecoxib do?

They are both types of pain relief medicine, often used to reduce pain and inflammation.

Why don't I know which medicine I'm getting?

This helps make sure the study results are fair and unbiased, without anyone's expectations affecting how they report their pain.

Will I still get regular pain relief if needed?

Your doctors will always ensure you receive appropriate pain management, regardless of your participation in the study.

What if I feel unwell during the study?

You should always tell the study team immediately if you experience any new or worsening symptoms.